Corrales-Bernal Andrea, Amparo Urango Luz, Rojano Benjamín, Maldonado Maria Elena
Arch Latinoam Nutr. 2014 Mar;64(1):16-23.
Mango pulp contains ascorbic acid, carotenoids, polyphenols, terpenoids and fiber which are healthy and could protect against colon cancer. The aim of this study was to evaluate the antiproliferative and preventive capacity of an aqueous extract of Mangifera indica cv. Azúcar on a human colon adenocarcinoma cell line (SW480) and in a rodent model of colorectal cancer, respectively. The content of total phenolics, flavonoids and carotenoids were also analyzed in the extract. SW480 cell growth was inhibited in a dose and time dependent manner by 22.3% after a 72h exposure to the extract (200 µg/ mL). Colon carcinogenesis was initiated in Balb/c mice by two intra-peritoneal injections of azoxymethane (AOM) at the third and fourth week of giving mango in drinking water (0.3%, 0.6%, 1.25%). After 10 weeks of treatment, in the colon of mice receiving 0.3% mango, aberrant crypt foci formation was inhibited more than 60% (p=0,05) and the inhibition was dose-dependent when compared with controls receiving water. These results show that mango pulp, a natural food, non toxic, part of human being diet, contains bioactive compounds able to reduce growth of tumor cells and to prevent the appearance of precancerous lesions in colon during carcinogenesis initiation.
芒果果肉含有抗坏血酸、类胡萝卜素、多酚、萜类化合物和纤维，这些成分有益健康，且可能预防结肠癌。本研究的目的是分别评估印度芒果品种阿苏卡尔水提取物对人结肠腺癌细胞系（SW480）和结直肠癌啮齿动物模型的抗增殖和预防能力。同时还分析了提取物中总酚、黄酮类化合物和类胡萝卜素的含量。在提取物（200µg/mL）作用72小时后，SW480细胞的生长以剂量和时间依赖性方式被抑制了22.3%。在给饮用水中添加芒果（0.3%、0.6%、1.25%）的第三和第四周，通过两次腹腔注射氧化偶氮甲烷（AOM）在Balb/c小鼠中引发结肠癌。治疗10周后，在接受0.3%芒果的小鼠结肠中异常隐窝灶形成被抑制超过60%（p = 0.05），与接受水的对照组相比，这种抑制呈剂量依赖性。这些结果表明，芒果果肉作为一种天然食品，无毒，是人类饮食的一部分，含有能够减少肿瘤细胞生长并在致癌起始阶段预防结肠癌前病变出现的生物活性化合物。
