原发性血小板增多症患者的链球菌感染后肾小球肾炎

Poststreptococcal glomerulonephritis in a patient with essential thrombocytosis.

作者信息

Ulusoy Sukru, Ozkan Gulsum, Sonmez Mehmet, Mungan Sevdegül, Köseoğlu Rahman, Cansız Muammer, Kaynar Kübra

机构信息

Department of Nephrology, School of Medicine, Karadeniz Technical University.

出版信息

J Nippon Med Sch. 2015;82(1):59-63. doi: 10.1272/jnms.82.59.

DOI:10.1272/jnms.82.59

PMID:25797878

Abstract

In addition to being the main cause of glomerulonephritis in children, poststreptococcal glomerulonephritis (PSGN) has recently been shown in older patients, especially those with malignancy or diabetes mellitus. The pathogenesis of PSGN has been ascribed to activation of complement 3 (C3) of the alternative complement cascade which, along with immunoglobulin (Ig) G and IgM deposits, is observed in renal tissue. Our aim here is to discuss the probable causes of PSGN developing with isolated IgM deposition in a 52-year-old patient with essential thrombocytosis followed-up over the previous 3.5 years. These characteristics make our case the first to be reported in the literature.

摘要

除了是儿童肾小球肾炎的主要病因外，近来有研究表明，链球菌感染后肾小球肾炎（PSGN）在老年患者中也较为常见，尤其是那些患有恶性肿瘤或糖尿病的患者。PSGN的发病机制被认为是替代补体途径中补体3（C3）的激活，在肾脏组织中可观察到其与免疫球蛋白（Ig）G和IgM沉积共存。本文旨在探讨一名52岁原发性血小板增多症患者，在过去3.5年的随访过程中，发生孤立性IgM沉积的PSGN的可能病因。这些特征使我们的病例成为文献报道中的首例。