伴孤立性C3沉积的新月体性急性肾小球肾炎：一例报告并文献复习
Crescentic acute glomerulonephritis with isolated C3 deposition: a case report and review of literature.
作者信息
Mao Song, Xuan Xiaoyan, Sha Yugen, Zhao Sanlong, Zhang Aihua, Huang Songming
机构信息
Department of Nephrology, Nanjing Children's Hospital, Affiliated to Nanjing Medical University Nanjing, China.
出版信息
Int J Clin Exp Pathol. 2015 Feb 1;8(2):1826-9. eCollection 2015.
An eight-year-old girl, presenting with palpebral edema, gross hematuria, and foam in urine, was admitted to our hospital. Investigations indicated increased serum antistreptolysin O (ASO) and anti-mycoplasma antibody titers. Renal biopsy showed crescentic poststreptococcal acute glomerulonephritis (CPAGN) with isolated C3 deposition in the glomeruli. Electro-microscope examination showed subepithelial deposition of electron dense material. She received the double pulse therapies of methylprednisolone and cyclophosphamide as well as the treatment of oral prednisolone, angiotensin converting enzyme-II (ACE-II) inhibitor, dipyridamole and traditional Chinese medicine. The complete clinical remission was achieved after 9 months. No serious adverse effects were observed during the follow-up. Our findings indicated that CPAGN with isolated C3 deposition might have a favorable prognosis after aggressive immunosuppressive treatment. However, the influence of isolated C3 deposition on CPAGN prognosis remains to be clarified.
一名8岁女孩因出现眼睑水肿、肉眼血尿和尿中泡沫而入住我院。检查显示血清抗链球菌溶血素O（ASO）和抗支原体抗体滴度升高。肾活检显示新月体性链球菌感染后急性肾小球肾炎（CPAGN），肾小球内有孤立的C3沉积。电镜检查显示电子致密物质的上皮下沉积。她接受了甲基强的松龙和环磷酰胺的双脉冲治疗以及口服强的松龙、血管紧张素转换酶-II（ACE-II）抑制剂、双嘧达莫和中药治疗。9个月后实现了完全临床缓解。随访期间未观察到严重不良反应。我们的研究结果表明，孤立C3沉积的CPAGN在积极的免疫抑制治疗后可能有良好的预后。然而，孤立C3沉积对CPAGN预后的影响仍有待阐明。
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