Perez G O, Rothfield N, Williams R C
Arch Intern Med. 1976 Mar;136(3):334-6.
Glomerulonephritis developed in a 42-year-old man with subacute bacterial endocarditis caused by an alpha-hemolytic Streptococcus. The patient showed hypocomplementemia and an elevated serum rheumatoid factor titer. Immunofluorescence microscopy of a renal biopsy specimen demonstrated granular deposits of IgM and C3 in all glomeruli studied. With the indirect immunofluores(ence technique and specific antiserum, the antigen in glomerular deposits was observed to correspond to the organism found in the blood cultures. These findings can be taken as further evidence that the glomerulonephritis of subacute bacterial enoocarditis represent an immune-complex disease.
一名42岁患有由α溶血性链球菌引起的亚急性细菌性心内膜炎的男性发生了肾小球肾炎。该患者表现为补体血症降低和血清类风湿因子滴度升高。对肾活检标本进行免疫荧光显微镜检查显示，在所有研究的肾小球中均有IgM和C3的颗粒状沉积。使用间接免疫荧光技术和特异性抗血清，观察到肾小球沉积物中的抗原与血培养中发现的微生物相对应。这些发现可作为进一步的证据，表明亚急性细菌性心内膜炎的肾小球肾炎是一种免疫复合物疾病。
