Rodríguez-Iturbe B, Carr R I, García R, Rabideau D, Rubio L, McIntosh R M
Clin Nephrol. 1980 Jan;13(1):1-4.
Acute poststreptococcal glomerulonephritis (APSGN) is a disease thought to be induced by the renal deposition of circulating immune complexes. In order to test this possibility, serum samples from 119 patients with APSGN were studied for Clq binding activity (ClqBA), levels of IgG, IgM, IgA, C3 and antibody titers to streptococcal enzymes. These parameters were analyzed in relation to the clinical and laboratory data of the acute nephritic syndrome and with respect to the time elapsed from streptococcal infection and from the onset of nephritis. Elevated ClqBA was found in 66.7% of the patients in the first week of the disease and this frequency decreased progressively to 17.6% after the second week. Normal ClqBA was found in patients after the third week of nephritis. Serum levels of IgG and IgM were elevated in over 95% of the patients. Levels of IgG in excess of 2400 mg/dl were detected in 71.1% of the cases. No correlation could be found between the ClqBA and the clinical or immunoserological findings of the disease. The data support the hypothesis that circulating immune complexes are responsible for the nephritis that follows streptococcal infection.
急性链球菌感染后肾小球肾炎（APSGN）被认为是一种由循环免疫复合物在肾脏沉积所诱发的疾病。为了验证这种可能性，对119例APSGN患者的血清样本进行了研究，检测其Clq结合活性（ClqBA）、IgG、IgM、IgA、C3水平以及抗链球菌酶抗体滴度。分析这些参数与急性肾炎综合征的临床和实验室数据的关系，以及与链球菌感染后和肾炎发病后经过的时间的关系。在疾病的第一周，66.7%的患者ClqBA升高，第二周后这一频率逐渐降至17.6%。肾炎第三周后的患者ClqBA正常。超过95%的患者血清IgG和IgM水平升高。71.1%的病例检测到IgG水平超过2400mg/dl。在ClqBA与该疾病的临床或免疫血清学结果之间未发现相关性。这些数据支持了循环免疫复合物是链球菌感染后肾炎病因的假说。
