Poulose Aby Cheruvathoor, Veeranarayanan Srivani, Mohamed M Sheikh, Nagaoka Yutaka, Aburto Rebeca Romero, Mitcham Trevor, Ajayan Pulickel M, Bouchard Richard R, Sakamoto Yasushi, Yoshida Yasuhiko, Maekawa Toru, Kumar D Sakthi
Bio Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan- 350-8585.
Department of Material Science and NanoEngineering, Rice University, 6100 Main Street, Houston, TX 77005, USA.
Nanoscale. 2015 May 14;7(18):8378-8388. doi: 10.1039/c4nr07139e.
A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.
开发了一种尺寸和形状经过调整的多功能金属硫族化物——基于Cu2S的纳米诊疗剂，用于针对脑癌细胞的三模态成像和多模态治疗。这种诊疗剂在光学、光声和X射线对比成像系统中效率很高。叶酸靶向的近红外响应光热消融与阿霉素的化疗作用协同，被证明是一种快速精确引导的癌症杀伤模块。纳米缀合物的多刺激，即pH、热和光响应药物释放行为，为按需触发给药开辟了更广阔的途径。简单的合成方案，结合单一纳米制剂中包含的众多有趣特性，清楚地证明了这种Cu2S纳米系统在未来癌症治疗策略中的竞争作用。
