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pH或/和光响应纳米载体的最新进展

Recent Advances in pH- or/and Photo-Responsive Nanovehicles.

作者信息

Shin Yuseon, Husni Patihul, Kang Kioh, Lee Dayoon, Lee Sehwa, Lee Eunseong, Youn Yuseok, Oh Kyungtaek

机构信息

Department of Global Innovative Drugs, The Graduate School of Chung-Ang University and College of Pharmacy, Chung-Ang University, 221 Heukseok-dong, Seoul 06974, Korea.

Division of Biotechnology, The Catholic University of Korea, Bucheon 14662, Korea.

出版信息

Pharmaceutics. 2021 May 14;13(5):725. doi: 10.3390/pharmaceutics13050725.

DOI:10.3390/pharmaceutics13050725
PMID:34069233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8157172/
Abstract

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

摘要

纳米技术与化疗相结合，通过开发基于纳米材料的肿瘤靶向给药系统（DDS），实现了更有效的药物设计。响应内部或外部信号的刺激响应性DDS可以精确控制预加载治疗药物的递送。在各种DDS中，光触发系统通过光的时空操纵提高了治疗的有效性和安全性。此外，pH诱导递送是针对实体瘤酸性微环境的研究最广泛的策略之一。因此，在本综述中，我们讨论了以光作为外源性信号或pH作为内源性触发因素来设计DDS的代表性策略。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63fd/8157172/5dc554a23187/pharmaceutics-13-00725-sch001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63fd/8157172/17c67716f7f7/pharmaceutics-13-00725-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63fd/8157172/2dbbf0552732/pharmaceutics-13-00725-g002.jpg
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