自闭症谱系障碍（ASD）儿童对联合/非联合注意的非典型前额叶皮质反应：一项功能近红外光谱研究。
Atypical prefrontal cortical responses to joint/non-joint attention in children with autism spectrum disorder (ASD): A functional near-infrared spectroscopy study.
作者信息
Zhu Huilin, Li Jun, Fan Yuebo, Li Xinge, Huang Dan, He Sailing
机构信息
Centre for Optical and Electromagnetic Research, ZJU-SCNU Joint Research Center of Photonics, South China Normal University (SCNU), Guangzhou, 510006, China ; These authors contributed equally.
Guangzhou Rehabilitation and Research Center for Children with ASD, Guangzhou, 510540, China.
出版信息
Biomed Opt Express. 2015 Feb 3;6(3):690-701. doi: 10.1364/BOE.6.000690. eCollection 2015 Mar 1.
Abstract
Autism spectrum disorder (ASD) is a neuro-developmental disorder, characterized by impairments in one's capacity for joint attention. In this study, functional near-infrared spectroscopy (fNIRS) was applied to study the differences in activation and functional connectivity in the prefrontal cortex between children with autism spectrum disorder (ASD) and typically developing (TD) children. 21 ASD and 20 TD children were recruited to perform joint and non-joint attention tasks. Compared with TD children, children with ASD showed reduced activation and atypical functional connectivity pattern in the prefrontal cortex during joint attention. The atypical development of left prefrontal cortex might play an important role in social cognition defects of children with ASD.
摘要
自闭症谱系障碍（ASD）是一种神经发育障碍，其特征在于个体的共同注意能力受损。在本研究中，功能近红外光谱技术（fNIRS）被用于研究自闭症谱系障碍（ASD）儿童与发育正常（TD）儿童在额叶皮质激活和功能连接方面的差异。招募了21名ASD儿童和20名TD儿童来执行共同和非共同注意任务。与TD儿童相比，ASD儿童在共同注意期间额叶皮质的激活减少且功能连接模式异常。左额叶皮质的非典型发育可能在ASD儿童的社会认知缺陷中起重要作用。
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