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A structural and dynamic molecular model for the sodium channel of Electrophorus electricus.

作者信息

Kosower E M

出版信息

FEBS Lett. 1985 Mar 25;182(2):234-42. doi: 10.1016/0014-5793(85)80306-9.

DOI:10.1016/0014-5793(85)80306-9
PMID:2579847
Abstract

Chemical logic and single group rotation (SGR) theory are applied to the primary structure determined by Noda et al. [(1984) Nature 312, 121-127] to construct a molecular model of the sodium channel of Electrophorus electricus. Both structural and dynamic aspects of the channel are accounted for, including gating current, sensitivity to changes in membrane potential, channel opening, a binding site for sodium, selectivity for sodium over potassium, capacity for rapid sodium flow, sensitivity to batrachotoxin (or other toxins) and inactivation.

摘要

相似文献

1
A structural and dynamic molecular model for the sodium channel of Electrophorus electricus.
FEBS Lett. 1985 Mar 25;182(2):234-42. doi: 10.1016/0014-5793(85)80306-9.
2
The structure of the voltage-sensitive sodium channel. Inferences derived from computer-aided analysis of the Electrophorus electricus channel primary structure.
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3
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4
Single-channel properties of the reconstituted voltage-regulated Na channel isolated from the electroplax of Electrophorus electricus.从电鳗电板分离出的重组电压门控钠通道的单通道特性。
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5
Toxins that modulate the sodium channel gating mechanism.
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6
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence.从cDNA序列推导的电鳗钠通道一级结构。
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7
Immunochemical properties and cytochemical localization of the voltage-sensitive sodium channel from the electroplax of the eel (Electrophorus electricus).鳗鱼（电鳗）电板中电压敏感钠通道的免疫化学特性及细胞化学定位
J Neurosci. 1983 Nov;3(11):2300-9. doi: 10.1523/JNEUROSCI.03-11-02300.1983.
8
Identification of phosphorylation sites for adenosine 3',5'-cyclic phosphate dependent protein kinase on the voltage-sensitive sodium channel from Electrophorus electricus.电鳗电压敏感性钠通道上依赖于3',5'-环磷酸腺苷的蛋白激酶磷酸化位点的鉴定。
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9
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10
Reconstituted voltage-sensitive sodium channel from Electrophorus electricus: chemical modifications that alter regulation of ion permeability.来自电鳗的重组电压敏感钠通道：改变离子通透性调节的化学修饰。
Proc Natl Acad Sci U S A. 1987 Sep;84(17):6282-6. doi: 10.1073/pnas.84.17.6282.

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Structure, function and expression of voltage-dependent sodium channels.电压依赖性钠通道的结构、功能与表达
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Biophys J. 1988 Sep;54(3):383-91. doi: 10.1016/S0006-3495(88)82971-0.
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