睡眠剥夺大脑中局部静息振荡的频率依赖性变化。
Frequency-dependent changes of local resting oscillations in sleep-deprived brain.
作者信息
Gao Lei, Bai Lijun, Zhang Yuchen, Dai Xi-jian, Netra Rana, Min Youjiang, Zhou Fuqing, Niu Chen, Dun Wanghuan, Gong Honghan, Zhang Ming
机构信息
Department of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
出版信息
PLoS One. 2015 Mar 23;10(3):e0120323. doi: 10.1371/journal.pone.0120323. eCollection 2015.
Sleep deprivation (SD) adversely affects brain function and is accompanied by frequency dependent changes in EEG. Recent studies have suggested that BOLD fluctuations pertain to a spatiotemporal organization with different frequencies. The present study aimed to investigate the frequency-dependent SD-related brain oscillatory activity by using the amplitude of low-frequency fluctuation (ALFF) analysis. The ALFF changes were measured across different frequencies (Slow-4: 0.027-0.073 Hz; Slow-5: 0.01-0.027 Hz; and Typical band: 0.01-0.08 Hz) in 24 h SD as compared to rested wakeful during resting-state fMRI. Sixteen volunteers underwent two fMRI sessions, once during rested wakefulness and once after 24 h of SD. SD showed prominently decreased ALFF in the right inferior parietal lobule (IPL), bilateral orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC), while increased ALFF in the visual cortex, left sensorimotor cortex and fusiform gyrus. Across the Slow-4 and Slow-5, results differed significantly in the OFC, DLPFC, thalamus and caudate in comparison to typical frequency band; and Slow-4 showed greater differences. In addition, negative correlations of behavior performance and ALFF patterns were found mainly in the right IPL across the typical frequency band. These observations provided novel insights about the physiological responses of SD, identified how it disturbs the brain rhythms, and linked SD with frequency-dependent alterations in amplitude patterns.
睡眠剥夺（SD）会对大脑功能产生不利影响，并伴随着脑电图中频率依赖性变化。最近的研究表明，血氧水平依赖（BOLD）波动与具有不同频率的时空组织有关。本研究旨在通过低频波动幅度（ALFF）分析来研究与睡眠剥夺相关的频率依赖性脑振荡活动。在静息态功能磁共振成像（fMRI）中，测量了24小时睡眠剥夺期间与清醒休息状态相比，不同频率（慢波4：0.027 - 0.073赫兹；慢波5：0.01 - 0.027赫兹；以及典型频段：0.01 - 0.08赫兹）下的ALFF变化。16名志愿者接受了两次fMRI检查，一次在清醒休息时，一次在24小时睡眠剥夺后。睡眠剥夺显示右侧顶下小叶（IPL）、双侧眶额皮质（OFC）和背外侧前额叶皮质（DLPFC）的ALFF显著降低，而视觉皮质、左侧感觉运动皮质和梭状回的ALFF增加。在慢波4和慢波5频段，与典型频段相比，OFC、DLPFC、丘脑和尾状核的结果有显著差异；慢波4频段的差异更大。此外，在典型频段上，行为表现与ALFF模式的负相关主要在右侧IPL中发现。这些观察结果为睡眠剥夺的生理反应提供了新的见解，确定了其如何扰乱脑节律，并将睡眠剥夺与幅度模式的频率依赖性改变联系起来。
Zotero 插件