长期完全睡眠剥夺降低健康男性被试的默认自发活动和连接模式：一项静息态 fMRI 研究。
Long-term total sleep deprivation decreases the default spontaneous activity and connectivity pattern in healthy male subjects: a resting-state fMRI study.
机构信息
Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China ; Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, People's Republic of China.
Beijing Key Lab of Applied Experimental Psychology, School of Psychology, and National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, People's Republic of China ; School of Education, Qufu Normal University, Qufu, Shandong, People's Republic of China.
出版信息
Neuropsychiatr Dis Treat. 2015 Mar 19;11:761-72. doi: 10.2147/NDT.S78335. eCollection 2015.
OBJECTIVE
The aim of this study is to use resting-state functional connectivity (rsFC) and amplitude of low-frequency fluctuation (ALFF) methods to explore intrinsic default-mode network (DMN) impairment after sleep deprivation (SD) and its relationships with clinical features.
METHODS
Twelve healthy male subjects underwent resting-state functional magnetic resonance imaging twice: once following rested wakefulness (RW) and the other following 72 hours of total SD. Before the scans, all subjects underwent the attention network test (ANT). The independent component analysis (ICA), rsFC, and ALFF methods were used to examine intrinsic DMN impairment. Receiver operating characteristic (ROC) curve was used to distinguish SD status from RW status.
RESULTS
Compared with RW subjects, SD subjects showed a lower accuracy rate (RW =96.83%, SD =77.67%; P<0.001), a slower reaction time (RW =695.92 ms; SD =799.18 ms; P=0.003), a higher lapse rate (RW =0.69%, SD =19.29%; P<0.001), and a higher intraindividual coefficient of variability in reaction time (RW =0.26, SD =0.33; P=0.021). The ICA method showed that, compared with RW subjects, SD subjects had decreased rsFC in the right inferior parietal lobule (IPL, BA40) and in the left precuneus (PrC)/posterior cingulate cortex (PCC) (BA30, 31). The two different areas were selected as regions of interest (ROIs) for future rsFC analysis. Compared with the same in RW subjects, in SD subjects, the right IPL showed decreased rsFC with the left PrC (BA7) and increased rsFC with the left fusiform gyrus (BA37) and the left cluster of middle temporal gyrus and inferior temporal gyrus (BA37). However, the left PrC/PCC did not show any connectivity differences. Compared with RW subjects, SD subjects showed lower ALFF area in the left IPL (BA39, 40). The left IPL, as an ROI, showed decreased rsFC with the right cluster of IPL and superior temporal gyrus (BA39, 40). ROC curve analysis showed that the area under the curve (AUC) value of the left IPL was 0.75, with a cutoff point of 0.834 (mean ALFF signal value). Further diagnostic analysis exhibited that the AUC alone discriminated SD status from RW status, with 75% sensitivity and 91.7% specificity.
CONCLUSION
Long-term SD disturbed the spontaneous activity and connectivity pattern of DMN.
目的
本研究旨在使用静息态功能连接(rsFC)和低频振幅(ALFF)方法来探索睡眠剥夺(SD)后固有默认模式网络(DMN)的损伤及其与临床特征的关系。
方法
12 名健康男性受试者在两次静息状态下接受功能磁共振成像扫描：一次是在清醒后休息(RW)后，另一次是在完全 SD 后 72 小时。在扫描前，所有受试者都进行了注意力网络测试(ANT)。使用独立成分分析(ICA)、rsFC 和 ALFF 方法来检测固有 DMN 的损伤。使用受试者工作特征(ROC)曲线来区分 SD 状态和 RW 状态。
结果
与 RW 受试者相比，SD 受试者的准确率较低(RW=96.83%，SD=77.67%；P<0.001)，反应时间较慢(RW=695.92ms；SD=799.18ms；P=0.003)，失误率较高(RW=0.69%，SD=19.29%；P<0.001)，反应时间的个体内变异系数较高(RW=0.26，SD=0.33；P=0.021)。ICA 方法显示，与 RW 受试者相比，SD 受试者右侧下顶叶(IPL，BA40)和左侧楔前叶/后扣带皮层(PrC/PCC)(BA30，31)的 rsFC 降低。这两个不同的区域被选为进一步 rsFC 分析的感兴趣区(ROI)。与 RW 受试者相比，SD 受试者的右侧 IPL 与左侧楔前叶(BA7)的 rsFC 降低，与左侧梭状回(BA37)和左侧颞中回和颞下回的簇(BA37)的 rsFC 增加。然而，左侧 PrC/PCC 没有显示出任何连接差异。与 RW 受试者相比，SD 受试者的左侧 IPL(BA39，40)的 ALFF 面积较低。左侧 IPL 作为一个 ROI，与右侧 IPL 和颞上回的簇(BA39，40)的 rsFC 降低。ROC 曲线分析显示，左侧 IPL 的曲线下面积(AUC)值为 0.75，截断点为 0.834(平均 ALFF 信号值)。进一步的诊断分析表明，AUC 可以单独区分 SD 状态和 RW 状态，具有 75%的敏感性和 91.7%的特异性。
结论
长期 SD 扰乱了 DMN 的自发活动和连接模式。
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