N-杂环卡宾催化环状β-烯胺酯与烯醛的环化反应：通往官能化吲哚并[2,3-a]喹嗪啶的途径
N-Heterocyclic carbene-catalyzed annulation of cyclic β-enamino esters with enals: access to functionalized indolo[2,3-a]quinolizidines.
作者信息
Hu Shihe, Wang Bingyang, Zhang Yu, Tang Weifang, Fang Mengyuan, Lu Tao, Du Ding
机构信息
State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing, 210009, P. R. China.
出版信息
Org Biomol Chem. 2015 Apr 28;13(16):4661-7. doi: 10.1039/c5ob00176e.
A novel synthetic approach to functionalized indolo[2,3-a]quinolizidines is developed via an N-heterocyclic carbene (NHC)-catalyzed annulation of cyclic β-enamino esters with enals . This methodology offers a pathway for quick and efficient construction of an indolo[2,3-a]quinolizidine skeleton which is a core structure of many natural products with diverse bioactivities.
通过N-杂环卡宾（NHC）催化的环状β-烯氨基酯与烯醛的环化反应，开发了一种合成功能化吲哚并[2,3-a]喹嗪啶的新方法。该方法为快速有效地构建吲哚并[2,3-a]喹嗪啶骨架提供了一条途径，该骨架是许多具有不同生物活性的天然产物的核心结构。
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