Senosiain Lalastra Carla, Foruny Olcina José Ramón
Servicio de Aparato Digestivo, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
Servicio de Aparato Digestivo, Hospital Universitario Ramón y Cajal, Madrid, España.
Gastroenterol Hepatol. 2015 Nov;38(9):549-55. doi: 10.1016/j.gastrohep.2015.01.006. Epub 2015 Mar 20.
Autoimmune pancreatitis is a benign fibroinflammatory disease of the pancreas of probable autoimmune origin, which includes 2 different phenotypes: type 1 (lymphoplasmacytic sclerosing pancreatitis) and type 2 (idiopathic duct-centric pancreatitis). Its clinical presentation as obstructive jaundice in patients with a pancreatic mass is common and therefore it must be included in the differential diagnosis of pancreatic neoplasia. Many diagnostic criteria have been described throughout history. The most famous are the HISORT criteria of the Mayo Clinic and the international consensus criteria of 2011. One of the main features of autoimmune pancreatitis is its dramatic response to steroid therapy, without the need for surgical treatment. Knowledge of this disease can dramatically change the management of patients with obstructive jaundice, who would otherwise be subjected to a pancreaticoduodenectomy.
自身免疫性胰腺炎是一种可能源于自身免疫的胰腺良性纤维炎症性疾病,包括两种不同的表型:1型(淋巴细胞浆细胞性硬化性胰腺炎)和2型(特发性导管中心性胰腺炎)。其临床表现为胰腺肿块患者出现梗阻性黄疸很常见,因此必须将其纳入胰腺肿瘤的鉴别诊断中。历史上已经描述了许多诊断标准。最著名的是梅奥诊所的HISORT标准和2011年的国际共识标准。自身免疫性胰腺炎的主要特征之一是对类固醇治疗有显著反应,无需手术治疗。了解这种疾病可以显著改变梗阻性黄疸患者的治疗方案,否则这些患者将接受胰十二指肠切除术。