Research in molecular biology in the past few years offers new views on vasomotor rhinitis. The key role of mediator substances which contain the mast cell and which, after degranulation, are active immediately by histamine release or act in a delayed manner (eg. leucotriene), is discussed, as well as the "liberofunction" of the neurotransmitter acetylcholine. The contribution to vasomotor rhinitis of other humoral systems, the kinine system and complement factors are also taken into account. The biopharmacological actions of the effector systems of the nasal mucosa (vessels, exocrine glands, nociceptors) are also analyzed. Using clinical examples the differentiation between humoral or neural reflex mediated hyperreflexia is worked out related to the classic triad of sneezing, profuse nasal discharge, nasal obstruction. The causes of vasomotor rhinitis (exogenous endogenous and drugs) are examined in the light of their pathophysiological importance. The differential diagnosis must cover allergic rhinopathy as well as the different kinds of rhinitis medicamentosa, the most important of which are discussed. Drugs which can help are discussed as well as continuous physical therapy.
过去几年分子生物学的研究为血管运动性鼻炎提供了新的观点。文中讨论了含有肥大细胞的介质物质的关键作用，这些物质在脱颗粒后，通过释放组胺立即发挥作用或以延迟方式起作用（如白三烯），以及神经递质乙酰胆碱的“释放功能”。还考虑了其他体液系统、激肽系统和补体因子对血管运动性鼻炎的作用。此外，还分析了鼻黏膜效应系统（血管、外分泌腺、伤害感受器）的生物药理作用。通过临床实例，针对打喷嚏、大量流涕、鼻塞这一经典三联征，阐述了体液或神经反射介导的反射亢进之间的区别。根据血管运动性鼻炎的病理生理重要性，研究了其病因（外源性、内源性和药物性）。鉴别诊断必须涵盖变应性鼻病以及不同类型的药物性鼻炎，文中讨论了其中最重要的几种。文中还讨论了可能有帮助的药物以及持续的物理治疗。
