Michaeli-Geller G, Zigdon-Giladi H
Refuat Hapeh Vehashinayim (1993). 2015 Jan;32(1):13-20, 59.
Alveolar bone resorption is the consequence of periodontal diseases, trauma or malignancies. Regeneration of the lost bone is crucial for the patient rehabilitation of function, phonetics and aesthetics. The surgical techniques for jaw-bone augmentation include: distraction osteogenesis, bone blocks (autologic/allogenic or xenogenic) and guided bone regeneration (GBR). These techniques have low predictability and high morbidity. As an alternative to the classical surgical approaches, in recent years, there have been developments in the field of tissue engineering which integrates the use of different scaffolds, growth factors and stem cells. This method aims to induce bone augmentation of large defects essentially mimicking biological processes that occure during craniofacial development. This article will review recent studies and a future outlook for the use of adult mesenchymal stem cells (MSC) and endothelial progenitor cells (EPC)--in order to induce bone augmentation in cases of severe bone resorption. Regenerative therapy using stem cells may open a new horizon in periodontology, maxillofacial surgery and implantology.
牙槽骨吸收是牙周疾病、创伤或恶性肿瘤的结果。缺失骨的再生对于患者功能、语音和美观的康复至关重要。颌骨增量的外科技术包括：牵张成骨、骨块（自体/同种异体或异种）和引导骨再生（GBR）。这些技术的可预测性低且发病率高。作为传统手术方法的替代方案，近年来，组织工程领域取得了进展，该领域整合了不同支架、生长因子和干细胞的使用。该方法旨在诱导大的骨缺损处的骨增量，基本上模拟颅面发育过程中发生的生物学过程。本文将综述近期关于使用成人间充质干细胞（MSC）和内皮祖细胞（EPC）以在严重骨吸收病例中诱导骨增量的研究及未来展望。使用干细胞的再生疗法可能会在牙周病学、颌面外科和种植学领域开辟新的前景。
