Dong Li Yan, Tan Ji Bin, Zhao Jing Lan, Jiang Fa Chun, Tian Xiao Cao, Ning Feng, Wang Shao Jie, Zhang Dong Feng, Pang Zeng Chang, Zhao Zhong Tang
School of Public Health, Shandong University, Jinan 250012, Shandong, China; Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
School of Public Health, Jilin University, Changchun 130021, Jilin, China; Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Biomed Environ Sci. 2015 Mar;28(3):235-8. doi: 10.3967/bes2015.033.
We assessed genetic and environmental effects on bone development of the hand and wrist, and on key anthropometric measures in Chinese young twins. In total, 139 monozygotic and 95 dizygotic twin pairs aged from 5 to 18 years were recruited. The twin correlations of total hand and wrist scores for monozygotic (MZ) and dizygotic (DZ) twins were 0.71 and 0.36, respectively. Bivariate model analysis showed moderate genetic correlations only for total skeletal maturity vs. weight and total skeletal maturity vs. waist circumference (r, 0.51 and 0.46, respectively). Our findings demonstrated that genetic factors played important roles in bone development of the hand and wrist in Chinese young twins, and that these genetic effects might be distinct from those influencing anthropometric measures.
