Harmsen Stefan, Bedics Matthew A, Wall Matthew A, Huang Ruimin, Detty Michael R, Kircher Moritz F
Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.
Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, United States.
Nat Commun. 2015 Mar 24;6:6570. doi: 10.1038/ncomms7570.
High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here we report the design and synthesis of a group of near-infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumour and disease marker detection.
高灵敏度和高特异性是生物医学成像中两个理想的特性。拉曼成像已成为一种有前景的光学模态，它兼具这两个特性。在此，我们报告了一组近红外吸收的2-噻吩基取代的硫属元素吡喃鎓染料的设计与合成，这些染料经设计对金具有高亲和力。当吸附到金纳米颗粒上时，这些染料会产生生物相容性的表面增强拉曼散射纳米探针，其检测限低至阿托摩尔，适用于体内超灵敏的多重肿瘤和疾病标志物检测。
