评价依鲁替尼治疗慢性免疫性血小板减少症患者的骨髓网硬蛋白纤维：EXTEND 研究的数据。
Evaluation of bone marrow reticulin in patients with chronic immune thrombocytopenia treated with eltrombopag: Data from the EXTEND study.
机构信息
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Department of Pathology, Weill Medical College of Cornell University, New York, New York.
出版信息
Am J Hematol. 2015 Jul;90(7):598-601. doi: 10.1002/ajh.24011.
Thrombopoietin receptor agonists, which raise platelet counts in patients with chronic immune thrombocytopenia, may be associated with increases in bone marrow (BM) reticulin. Patients with chronic immune thrombocytopenia participating in the Eltrombopag Extended Dosing (EXTEND) study underwent BM biopsies to identify clinically relevant BM fibrosis-related increases. Specimens were centrally reviewed by 2 hematopathologists. Two hundred thirty-two biopsy specimens were collected from 117 patients treated for ≤5.5 years. Moderate to marked reticulin fibrosis was found in 2 patients. After withdrawing from the study, the biopsy of 1 patient reverted to normal. There were no other pathologic changes identified among on-treatment specimens, and no pattern of abnormal reticulin deposition associated with eltrombopag treatment was evident.
促血小板生成素受体激动剂可提高慢性免疫性血小板减少症患者的血小板计数，可能与骨髓（BM）网状纤维增加有关。参与艾曲泊帕延长剂量（EXTEND）研究的慢性免疫性血小板减少症患者接受了骨髓活检，以确定与临床相关的 BM 纤维化相关增加。标本由 2 位血液病理学家进行中心审查。对 117 名接受治疗≤5.5 年的患者采集了 232 份活检标本。2 例患者发现中度至明显网状纤维纤维化。在退出研究后，1 例患者的活检标本恢复正常。治疗期间的标本未发现其他病理变化，也没有发现与艾曲泊帕治疗相关的异常网状纤维沉积模式。
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