Nesher G, Soriano A, Shlomai G, Iadgarov Y, Shulimzon T R, Borella E, Dicker D, Shoenfeld Y
Department of Internal Medicine A, Shaare Zedek Medical Center and the Hebrew University Medical School, Jerusalem, Israel
Department of Clinical Medicine and Rheumatology, Campus Bio-Medico University, Rome, Italy.
Lupus. 2015 Apr;24(4-5):463-8. doi: 10.1177/0961203314562622.
Silicone has been considered biologically inert; thus it has been employed in many medical devices and nowadays is commonly used in plastic surgery for mammary prosthesis. It is well tolerated in most cases. However, autoimmune disorders and siliconomas with granulomatous reactions after silicone implant rupture have been described. We report cases of four women who developed systemic disorders following rupture of silicone breast implants resulting in lymph node and thoracic silicone infiltration. The symptoms in these cases, including arthralgia, myalgia, generalized weakness, severe fatigue, sleeping disturbances, cognitive impairment, memory loss, irritable bowel syndrome, and weight loss, clearly match the criteria of the recently defined autoimmune/inflammatory syndrome induced by adjuvants (ASIA).
硅酮一直被认为具有生物惰性；因此它已被应用于许多医疗设备中，如今在整形外科中常用于乳房假体。在大多数情况下，它的耐受性良好。然而，已有报道称硅酮植入物破裂后会出现自身免疫性疾病和伴有肉芽肿反应的硅瘤。我们报告了4名女性的病例，她们在硅酮乳房植入物破裂后出现了全身性疾病，导致淋巴结和胸腔硅酮浸润。这些病例中的症状，包括关节痛、肌痛、全身无力、严重疲劳、睡眠障碍、认知障碍、记忆力减退、肠易激综合征和体重减轻，显然符合最近定义的由佐剂诱导的自身免疫性/炎症性综合征（ASIA）的标准。
