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女性硅酮乳房植入物与认知障碍、睡眠障碍和抑郁：与自主神经系统受体自身抗体的关联。

Cognitive Impairment, Sleep Disturbance, and Depression in Women with Silicone Breast Implants: Association with Autoantibodies against Autonomic Nervous System Receptors.

机构信息

Department of Medicine C, Wolfson Medical Center, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Ramat Gan 52621, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

出版信息

Biomolecules. 2022 Jun 2;12(6):776. doi: 10.3390/biom12060776.

DOI:10.3390/biom12060776
PMID:35740901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9221347/
Abstract

BACKGROUND

Silicone breast implants (SBIs) has been shown to be associated with an increased risk of autoimmune diseases. In the current study, we aimed to explore the potential association between circulating autoantibodies against the autonomic nervous system and cognitive impairment, memory deficit, and depressive symptoms reported by women with SBIs.

METHODS

ELISA assays were used to quantify anti-adrenergic receptors (α1, α2, β1, β2), anti-muscarinic receptors (M1-M5), anti-endothelin receptor type A, and anti-angiotensin II type 1 receptor titers in the sera of 93 symptomatic female subjects with SBIs and 36 age-matched healthy female controls.

RESULTS

A significant difference was detected in the level of autoantibodies against the autonomic nervous system receptors in women with SBIs who reported memory impairment, cognitive impairment, and sleep disturbance as compared with both women with SBIs who did not complain of these symptoms or with healthy individuals without SBIs.

CONCLUSIONS

Clinical symptoms such as depression, cognitive impairment, and sleep disturbances were found to be associated with dysregulation of the levels of circulating autoantibodies targeting the autonomous nervous system receptors in women with SBIs. These autoantibodies may have diagnostic significance in diseases associated with breast implants.

摘要

背景

已有研究表明，硅酮乳房植入物（SBIs）与自身免疫性疾病的风险增加有关。在本研究中，我们旨在探讨循环中针对自主神经系统的自身抗体与 SBI 女性报告的认知障碍、记忆缺陷和抑郁症状之间的潜在关联。

方法

采用 ELISA 法检测 93 例有症状的 SBI 女性患者和 36 名年龄匹配的健康女性对照者血清中抗肾上腺素能受体（α1、α2、β1、β2）、抗毒蕈碱受体（M1-M5）、抗内皮素受体 A 和抗血管紧张素 II 型 1 受体的滴度。

结果

与没有这些症状的 SBI 女性或没有 SBI 的健康个体相比，报告有记忆障碍、认知障碍和睡眠障碍的 SBI 女性的自主神经系统受体自身抗体水平存在显著差异。

结论

研究发现，抑郁、认知障碍和睡眠障碍等临床症状与 SBI 女性循环中针对自主神经系统受体的自身抗体水平失调有关。这些自身抗体在与乳房植入物相关的疾病中可能具有诊断意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b4/9221347/6edb43d7f66a/biomolecules-12-00776-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b4/9221347/ba851a5311e9/biomolecules-12-00776-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b4/9221347/3cd4d2f16d0b/biomolecules-12-00776-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b4/9221347/352c0ecc87c5/biomolecules-12-00776-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b4/9221347/6edb43d7f66a/biomolecules-12-00776-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b4/9221347/ba851a5311e9/biomolecules-12-00776-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b4/9221347/3cd4d2f16d0b/biomolecules-12-00776-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b4/9221347/352c0ecc87c5/biomolecules-12-00776-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15b4/9221347/6edb43d7f66a/biomolecules-12-00776-g004.jpg

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