Abdalla Sala, Macneal Peter, Borg Cynthia-Michelle
Department of General Surgery, University Hospital Lewisham, London, UK
Department of General Surgery, University Hospital Lewisham, London, UK.
J Surg Case Rep. 2015 Mar 22;2015(3):rjv028. doi: 10.1093/jscr/rjv028.
Gastrointestinal (GI) metastases from primary breast carcinoma are rare but more common in invasive lobular carcinoma than invasive ductal carcinoma. The symptoms may be non-specific and the presentation can occur many years after the initial primary breast carcinoma. Radiological and endoscopic findings can be difficult to distinguish from inflammatory bowel disease and primary carcinoma of the GI tract. Histological and immunohistopathology assessment will usually confirm the diagnosis of metastatic breast carcinoma. We report the first case of lobular breast carcinoma metastasizing to the terminal ileum and ileocaecal valve 19 years following treatment for breast cancer in an 82-year-old woman. Staging investigations revealed synchronous metastases in bones and the pleura. A high index of suspicion and awareness of the potential long interval in the presentation of metastatic breast cancer help in making an accurate diagnosis and rapid clinical management.
原发性乳腺癌的胃肠道转移很少见,但浸润性小叶癌比浸润性导管癌更常见。症状可能不具特异性,且常在原发性乳腺癌初次发病多年后出现。放射学和内镜检查结果可能难以与炎症性肠病及胃肠道原发性癌相区分。组织学和免疫组织病理学评估通常可确诊转移性乳腺癌。我们报告了首例82岁女性在乳腺癌治疗19年后,小叶乳腺癌转移至回肠末端和回盲瓣的病例。分期检查显示骨骼和胸膜有同步转移。对转移性乳腺癌表现的高怀疑指数和对其可能存在的较长间隔期的认识,有助于做出准确诊断和进行快速临床处理。