Shanks G Dennis
Australian Army Malaria Institute, Enoggera, Australia; University of Queensland, School of Population Health, Brisbane, Australia; Department of Zoology, University of Oxford, Oxford, United Kingdom
Am J Trop Med Hyg. 2015 May;92(5):941-2. doi: 10.4269/ajtmh.14-0792. Epub 2015 Mar 23.
At the end of World War I, British medical officers noted that soldiers infected with malaria were more likely to die during the 1918 influenza pandemic than those without malaria. This synergistic mortality appeared to be specific to Plasmodium falciparum and has not been generally noted since 1920. A possible explanation is that a malaria-induced procoagulant state enhanced the activation of influenza virus to increase inflammation and subsequent severe clinical outcomes. Falciparum proteins bind and likely inhibit antithrombin 3 and other factors. Pathogens interact in ways that may inform pathophysiology studies of remote epidemics.
第一次世界大战结束时，英国军医注意到，感染疟疾的士兵在1918年流感大流行期间比未感染疟疾的士兵更有可能死亡。这种协同死亡率似乎是恶性疟原虫所特有的，自1920年以来就没有被普遍注意到。一种可能的解释是，疟疾诱导的促凝状态增强了流感病毒的激活，从而增加炎症和随后的严重临床结果。恶性疟原虫蛋白结合并可能抑制抗凝血酶3和其他因子。病原体之间的相互作用方式可能为远程流行病的病理生理学研究提供信息。
