Chang Nan-Shan
Experimental Biology and Medicine, Institute of Molecular Medicine, National Cheng Kung University, Tainan, 70101 Taiwan; Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY, 13210 USA; Department of Neurochemistry, NYS Institute of Basic Research for Developmental Disabilities, Staten Island, NY, 10314 USA
Exp Biol Med (Maywood). 2015 Mar;240(3):281-4. doi: 10.1177/1535370215574226.
Since its discovery in 2000, WW domain-containing oxidoreductase (WWOX, FOR or WOX1) has been considered as a tumor suppressor protein. Global research focus has been aimed mainly toward this direction. In this thematic issue, updated information has been collected regarding the structure, function and signaling of WWOX, along with its critical role as a tumor suppressor and participation in metabolism, neurodegeneration, ataxia, epilepsy, neural disorders, neuronal damages, and interactions with oncogenic viruses. WWOX is not a driver of cancer initiation. Chromosomal alterations in the WWOX gene enhance cancer progression. Importantly, a homozygous nonsense mutation of WWOX gene in humans leads to neural pathologies and early death, rather than spontaneous cancer development. These findings suggest new physiological functions of WWOX in metabolism and neural diseases, and these areas require further investigation.
自2000年被发现以来，含WW结构域的氧化还原酶（WWOX，FOR或WOX1）一直被视为一种肿瘤抑制蛋白。全球研究重点主要集中在这个方向。在本期专题中，已收集了有关WWOX的结构、功能和信号传导的最新信息，以及其作为肿瘤抑制因子的关键作用，及其参与代谢、神经退行性变、共济失调、癫痫、神经疾病、神经元损伤以及与致癌病毒相互作用的相关信息。WWOX不是癌症起始的驱动因素。WWOX基因的染色体改变会促进癌症进展。重要的是，人类WWOX基因的纯合无义突变会导致神经病理学和早期死亡，而不是自发的癌症发展。这些发现提示了WWOX在代谢和神经疾病中的新生理功能，这些领域需要进一步研究。
