Hladinova Z, Hruskova Z, Svobodova B, Malickova K, Lanska V, Konopásek P, Jancova E, Rysava R, Edelstein C L, Tesar V
Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic ; Institute of Immunology and Microbiology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
Mediators Inflamm. 2015;2015:603750. doi: 10.1155/2015/603750. Epub 2015 Feb 23.
ST2, a member of the interleukin-1 receptor family, is selectively expressed on Th2 cells and mediates important Th2 functions. IL-33 is a specific ligand of ST2. The aim of the study was to determine whether serum levels of soluble ST2 (sST2) or IL-33 predict activity of the disease in patients with ANCA-associated vasculitides (AAV).
139 AAV patients and 62 controls were studied. IL-33 and sST2 in the blood were measured with a commercially available ELISA.
Newly diagnosed AAV patients had higher sST2 levels than controls (P < 0.01). Levels of sST2 were significantly higher in active newly diagnosed AAV patients than in patients with remission (P < 0.001). IL-33 levels were higher in AAV patients than in the control groups (P = 0.002). However, serum IL-33 levels were not increased in patients with active AAV compared to patients in remission. IL-33 levels were higher in patients with granulomatosis with polyangiitis than in patients with microscopic polyangiitis (P = 0.012).
Serum sST2, but not serum IL-33, may be a marker of activity in AAV patients.
ST2是白细胞介素-1受体家族的成员，在Th2细胞上选择性表达并介导重要的Th2功能。IL-33是ST2的特异性配体。本研究旨在确定可溶性ST2（sST2）或IL-33的血清水平是否可预测抗中性粒细胞胞浆抗体相关性血管炎（AAV）患者的疾病活动度。
对139例AAV患者和62例对照者进行研究。采用市售酶联免疫吸附测定法（ELISA）检测血液中的IL-33和sST2。
新诊断的AAV患者的sST2水平高于对照组（P<0.01）。新诊断的活动期AAV患者的sST2水平显著高于缓解期患者（P<0.001）。AAV患者的IL-33水平高于对照组（P = 0.002）。然而，与缓解期患者相比，活动期AAV患者的血清IL-33水平并未升高。肉芽肿性多血管炎患者的IL-33水平高于显微镜下多血管炎患者（P = 0.012）。
血清sST2而非血清IL-33可能是AAV患者疾病活动度的一个标志物。
