Ünal Betül, Başsorgun Cumhur İbrahim, Çil Gönülcü Sinem, Uçar Aslı, Çelik Fatih, Elpek Gülsüm Özlem
Department of Pathology, School of Medicine, Akdeniz University, Turkey.
Case Rep Med. 2015;2015:348204. doi: 10.1155/2015/348204. Epub 2015 Feb 23.
Here we present an eleven-year-old male patient who had been diagnosed with common variable immunodeficiency (CVID) three years ago due to recurrent sinopulmonary infections. Two years later he had been diagnosed with Crohn's disease (CD) due to diarrhea episodes which were unresponsive to the treatment. Depending on the active gastrointestinal bleeding and perforation he underwent total colectomy. Despite immunoglobulin and antiviral therapies, general condition of patient deteriorated and he died in the postoperative seventh day. Laboratory analysis was seronegative. CMV inclusion containing cells were detected in postmortem biopsies taken from liver, lungs, and lymph nodes.
我们在此介绍一名11岁男性患者，该患者三年前因反复发生鼻窦肺部感染被诊断为普通变异型免疫缺陷（CVID）。两年后，他因腹泻发作且治疗无效被诊断为克罗恩病（CD）。鉴于活动性胃肠道出血和穿孔，他接受了全结肠切除术。尽管进行了免疫球蛋白和抗病毒治疗，但患者的总体状况仍恶化，并于术后第七天死亡。实验室分析为血清阴性。在取自肝脏、肺和淋巴结的尸检活检中检测到含有巨细胞病毒包涵体的细胞。
