Zeng Zhao-Cheng, Chang Qing, Sun Zhi-Wei, Song Ming-Mei, Jin Xin-Ling, Jiang Shu-Ya, Yang Xia
Department of Pediatrics, No.101 Hospital of the PLA, Wuxi, Jiangsu, China (mainland).
Department of Pediatrics, Wuxi No. 8 People's Hospital, Wuxi, Jiangsu, China (mainland).
Med Sci Monit. 2017 Mar 11;23:1242-1246. doi: 10.12659/msm.898589.
BACKGROUND The aim of this study was to investigate the involvement of CMV infection in wheezing infants and the association between CMV-DNA and immunoglobulins (Igs). MATERIAL AND METHODS A total of 243 wheezing infants and 3,000 parturients were enrolled in this study. The infants were randomly grouped to receive blood HCMV-DNA tests (n=46) or urine HCMV-DNA tests (n=197). Furthermore, all participants had serum CMV-specific IgM and IgG testing. Afterwards, 10 HCMV-IgG positive infants were randomly selected for simultaneous blood and urine HCMV-DNA tests, and 25 HCMV-IgG positive puerperants were randomly selected for urine HCMV-DNA tests. RESULTS The detection rate of urine HCMV-DNA was significantly higher than that of blood HCMV-DNA (67.5% vs. 13.0%, p<0.001). Fifteen (6.2%) and 190 (80.0%) infants showed positive CMV-specific IgM and IgG results (p<0.001), respectively. Among the 10 HCMV-IgG positive infants tested further, only two infants had positive HCMV-DNA blood tests, while all of the 10 infants had positive HCMV-DNA urine tests. However, HCMV-DNA was not detected in the urine of the 25 randomly selected parturients positive for HCMV-IgG. CONCLUSIONS CMV infection may be one of the causes of wheezing in infants; CMV infection can be detected by urine-HCMV-DNA and serum HCMV-IgG testing. Infants were more susceptible to CMV infection than parturients.
背景 本研究旨在调查巨细胞病毒（CMV）感染在喘息婴儿中的情况以及CMV-DNA与免疫球蛋白（Igs）之间的关联。材料与方法 本研究共纳入243例喘息婴儿和3000例产妇。将婴儿随机分组进行血液HCMV-DNA检测（n = 46）或尿液HCMV-DNA检测（n = 197）。此外，所有参与者均进行血清CMV特异性IgM和IgG检测。之后，随机选择10例HCMV-IgG阳性婴儿同时进行血液和尿液HCMV-DNA检测，随机选择25例HCMV-IgG阳性产妇进行尿液HCMV-DNA检测。结果 尿液HCMV-DNA的检出率显著高于血液HCMV-DNA（67.5% 对13.0%，p<0.001）。分别有15例（6.2%）和190例（80.0%）婴儿的CMV特异性IgM和IgG结果呈阳性（p<0.001）。在进一步检测的10例HCMV-IgG阳性婴儿中，只有2例婴儿血液HCMV-DNA检测呈阳性，而所有10例婴儿尿液HCMV-DNA检测均呈阳性。然而，在随机选择的25例HCMV-IgG阳性产妇的尿液中未检测到HCMV-DNA。结论 CMV感染可能是婴儿喘息的原因之一；可通过尿液-HCMV-DNA和血清HCMV-IgG检测来检测CMV感染。婴儿比产妇更容易感染CMV。
