黄烷-异黄烷重排：通过1,2-迁移-烷基化序列实现对异黄酮类化合物的仿生合成途径。
The flavan-isoflavan rearrangement: bioinspired synthetic access to isoflavonoids via 1,2-shift-alkylation sequence.
作者信息
Nakamura Kayo, Ohmori Ken, Suzuki Keisuke
机构信息
Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro, Tokyo 152-8551, Japan.
出版信息
Chem Commun (Camb). 2015 Apr 25;51(32):7012-4. doi: 10.1039/c5cc01572c. Epub 2015 Mar 24.
PMID:25803199
Abstract
An approach to 2-substituted isoflavonoids is reported based on the 1,2-shift of the aryl group in the catechin skeleton followed by the in situ alkylation. Synthesis of (-)-equol, a natural isoflavan with estrogenic activities, was achieved.
摘要
报道了一种基于儿茶素骨架中芳基的1,2-迁移然后进行原位烷基化反应来合成2-取代异黄酮的方法。实现了具有雌激素活性的天然异黄酮（-）-雌马酚的合成。
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