Gayler Kevin M, Lambert Kyle M, Wood John L
Department of Chemistry and Biochemistry, Baylor University, Waco, TX, 76798, USA.
Tetrahedron. 2019 Jun 14;75(24):3154-3159. doi: 10.1016/j.tet.2019.01.032. Epub 2019 Jan 21.
The 2,5-diketopiperazine (DKP) moiety is a core feature of many natural products and medicinally relevant scaffolds. As part of our efforts directed towards a total synthesis of penicisulfuranol B, we have developed and report herein: (1) the preparation of an diketopiperazine intermediate accessible via a molybdenum-mediated oxidation of a parent diketopiperazine, and (2) further synthetic studies leading to a novel spirocyclic dihydrobenzofuran-containing diketopiperazine.
2,5-二酮哌嗪（DKP）部分是许多天然产物和具有药用价值的骨架的核心特征。作为我们全合成青霉硫呋醇B工作的一部分，我们在此开发并报告：（1）通过钼介导的母体二酮哌嗪氧化制备一种二酮哌嗪中间体，以及（2）进一步的合成研究，得到一种含新型螺环二氢苯并呋喃的二酮哌嗪。
