Synthesis of phytoestrogenic isoflavonoid disulfates.

作者信息

Soidinsalo Otto, Wähälä Kristiina

机构信息

Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, A.I. Virtasen aukio 1, P.O. Box 55, 00014 Helsinki, Finland.

出版信息

Steroids. 2004 Sep;69(10):613-6. doi: 10.1016/j.steroids.2004.03.015.

DOI:10.1016/j.steroids.2004.03.015

PMID:15465105

Abstract

Di-O-sulfates of six phytoestrogenic isoflavonoids, daidzein (1), genistein (2), glycitein (3), and the reduced metabolites dihydrodaidzein (4), dihydrogenistein (5) and equol (6) were synthesized. These compounds are known or potential inhibitors of steroid sulfatase enzymes. The new compounds were characterized by NMR and mass spectrometry.

摘要