van Dijk S C, de Jongh R T, Enneman A W, Ham A C, Swart K M A, van Wijngaarden J P, van der Zwaluw N L, Brouwer-Brolsma E M, van Schoor N M, Dhonukshe-Rutten R A M, Lips P, de Groot C P G M, Smulders Y M, Blom H J, Feskens E J, Geleijnse J M, van den Meiracker A H, Mattace Raso F U S, Uitterlinden A G, Zillikens M C, van der Velde N
Section of Geriatrics, Department of Internal Medicine, Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.
J Bone Miner Metab. 2016 Jan;34(1):99-108. doi: 10.1007/s00774-015-0650-x. Epub 2015 Mar 25.
Several studies have observed positive associations between bone disease and cardiovascular disease. A potential common pathway is hyperhomocysteinemia; however, to date, there is a lack of data regarding hyperhomocysteinemic populations. Therefore, we examined both cross-sectionally and longitudinally, whether there is an association between bone parameters and arterial stiffness in a hyperhomocysteinemic population, and investigated the potential common role of homocysteine (hcy) level on these associations. Cross-sectional and longitudinal data of the B-PROOF study were used (n = 519). At both baseline and 2-year follow-up we determined bone measures-incident fractures and history of fractures, bone-mineral density (BMD) and quantitative ultrasound (QUS) measurement. We also measured arterial stiffness parameters at baseline-pulse wave velocity, augmentation index and aortic pulse pressure levels with applanation tonometry. Linear regression analysis was used to examine these associations and we tested for potential interaction of hcy level. The mean age of the study population was 72.3 years and 44.3 % were female. Both cross-sectionally and longitudinally there was no association between arterial stiffness measures and BMD or QUS measurements or with incident fractures (n = 16) within the 2-3 years of follow-up. Hcy level did not modify the associations and adjustment for hcy did not change the results. Arterial stiffness was not associated with bone parameters and fractures, and hcy neither acted as a pleiotropic factor nor as a mediator. The potential association between bone and arterial stiffness is therefore not likely to be driven by hyperhomocysteinemia.
多项研究观察到骨病与心血管疾病之间存在正相关关系。一个潜在的共同途径是高同型半胱氨酸血症；然而，迄今为止，缺乏关于高同型半胱氨酸血症人群的数据。因此，我们进行了横断面和纵向研究，以探讨在高同型半胱氨酸血症人群中骨参数与动脉僵硬度之间是否存在关联，并研究同型半胱氨酸（hcy）水平在这些关联中可能发挥的共同作用。我们使用了B-PROOF研究的横断面和纵向数据（n = 519）。在基线和2年随访时，我们测定了骨指标——新发骨折和骨折病史、骨密度（BMD）和定量超声（QUS）测量值。我们还在基线时使用压平式眼压计测量了动脉僵硬度参数——脉搏波速度、增强指数和主动脉脉压水平。采用线性回归分析来检验这些关联，并测试hcy水平的潜在相互作用。研究人群的平均年龄为72.3岁，44.3%为女性。在横断面和纵向研究中，动脉僵硬度测量值与BMD或QUS测量值之间，以及与随访2 - 3年内的新发骨折（n = 16）之间均无关联。hcy水平并未改变这些关联，对hcy进行校正也未改变结果。动脉僵硬度与骨参数和骨折无关，hcy既不是多效性因素，也不是介导因素。因此，骨与动脉僵硬度之间的潜在关联不太可能由高同型半胱氨酸血症驱动。
