Department of Craniofacial Development & Stem Cell Biology, King's College London, London SE1 9RT, UK
EMBL-CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, 08003 Barcelona, Spain Institucio Catalana de Recerca i Estudis Avancats (ICREA), Passeig Lluis Companys 23, 08010 Barcelona, Spain
Development. 2015 Apr 1;142(7):1203-11. doi: 10.1242/dev.114991.
One of the most fundamental questions in biology is that of biological pattern: how do the structures and shapes of organisms arise? Undoubtedly, the two most influential ideas in this area are those of Alan Turing's 'reaction-diffusion' and Lewis Wolpert's 'positional information'. Much has been written about these two concepts but some confusion still remains, in particular about the relationship between them. Here, we address this relationship and propose a scheme of three distinct ways in which these two ideas work together to shape biological form.
生物体的结构和形状是如何产生的？毫无疑问，这一领域最有影响力的两个观点是艾伦·图灵的“反应扩散”和刘易斯·沃尔珀特的“位置信息”。关于这两个概念已经有很多文献，但仍存在一些混淆，特别是它们之间的关系。在这里，我们解决了这个关系，并提出了一个方案，说明这两个观点以三种不同的方式共同作用来塑造生物形态。
