计算生物学：图灵的简约之道。
Computational biology: Turing's lessons in simplicity.
机构信息
Centre for Craniofacial Regeneration and Biology, King's College London, London, United Kingdom.
出版信息
Biophys J. 2021 Oct 5;120(19):4139-4141. doi: 10.1016/j.bpj.2021.08.041. Epub 2021 Sep 2.
Abstract
Biophysical modeling of development started with Alan Turing. His two-morphogen reaction-diffusion model was a radical but powerful simplification. Despite its apparent limitations, the model captured real developmental processes that only recently have been validated at the molecular level in many systems. The precision and robustness of reaction-diffusion patterning, despite boundary condition-dependence, remain active areas of investigation in developmental biology.
摘要
发育的生物物理建模始于艾伦·图灵。他的双形态发生物反应扩散模型是一种激进但强大的简化。尽管存在明显的局限性，但该模型捕捉到了真实的发育过程，这些过程直到最近才在许多系统的分子水平上得到验证。反应扩散模式的精确性和鲁棒性，尽管依赖于边界条件，仍然是发育生物学中活跃的研究领域。
相似文献
1
Computational biology: Turing's lessons in simplicity.计算生物学：图灵的简约之道。
Biophys J. 2021 Oct 5;120(19):4139-4141. doi: 10.1016/j.bpj.2021.08.041. Epub 2021 Sep 2.
2
Introduction to 'Recent progress and open frontiers in Turing's theory of morphogenesis'.介绍“图灵形态发生理论的最新进展和前沿领域”。
Philos Trans A Math Phys Eng Sci. 2021 Dec 27;379(2213):20200280. doi: 10.1098/rsta.2020.0280. Epub 2021 Nov 8.
3
Insights from chemical systems into Turing-type morphogenesis.从化学系统到图灵型形态发生的见解。
Philos Trans A Math Phys Eng Sci. 2021 Dec 27;379(2213):20200269. doi: 10.1098/rsta.2020.0269. Epub 2021 Nov 8.
4
Modern perspectives on near-equilibrium analysis of Turing systems.现代视角下的图灵系统近平衡分析
Philos Trans A Math Phys Eng Sci. 2021 Dec 27;379(2213):20200268. doi: 10.1098/rsta.2020.0268. Epub 2021 Nov 8.
5
Turing's theory of morphogenesis of 1952 and the subsequent discovery of the crucial role of local self-enhancement and long-range inhibition.图灵 1952 年的形态发生理论，以及随后发现局部自我增强和远程抑制的关键作用。
Interface Focus. 2012 Aug 6;2(4):407-16. doi: 10.1098/rsfs.2011.0097. Epub 2012 Feb 8.
6
Selection, growth and form. Turing's two biological paths towards intelligent machinery.选择、生长和形态。图灵通往智能机器的两条生物学路径。
Stud Hist Philos Sci. 2024 Aug;106:126-135. doi: 10.1016/j.shpsa.2024.05.017. Epub 2024 Jul 2.
7
Aberrant behaviours of reaction diffusion self-organisation models on growing domains in the presence of gene expression time delays.存在基因表达时间延迟时，生长域上反应扩散自组织模型的异常行为。
Bull Math Biol. 2010 Nov;72(8):2161-79. doi: 10.1007/s11538-010-9533-4. Epub 2010 Mar 23.
8
Turing's model for biological pattern formation and the robustness problem.图灵的生物模式形成模型与鲁棒性问题。
Interface Focus. 2012 Aug 6;2(4):487-96. doi: 10.1098/rsfs.2011.0113. Epub 2012 Feb 8.
9
Positional information and reaction-diffusion: two big ideas in developmental biology combine.位置信息与反应扩散：发育生物学中的两大理念交汇
Development. 2015 Apr 1;142(7):1203-11. doi: 10.1242/dev.114991.
10
Investigating the Turing conditions for diffusion-driven instability in the presence of a binding immobile substrate.研究在存在结合不动底物的情况下扩散驱动不稳定性的图灵条件。
J Theor Biol. 2015 Feb 21;367:286-295. doi: 10.1016/j.jtbi.2014.11.024. Epub 2014 Dec 4.
引用本文的文献
1
A pattern of villification.绒毛化模式。
Nat Mater. 2024 Aug;23(8):1010. doi: 10.1038/s41563-024-01964-3.
2
Resilience of the replacing dentition in adult reptiles.成年爬行动物替换齿列的韧性。
Dev Biol. 2024 Dec;516:71-81. doi: 10.1016/j.ydbio.2024.07.013. Epub 2024 Jul 24.
3
Patterning, From Conifers to Consciousness: Turing's Theory and Order From Fluctuations.模式形成，从针叶树到意识：图灵理论与波动产生的秩序
Front Cell Dev Biol. 2022 May 3;10:871950. doi: 10.3389/fcell.2022.871950. eCollection 2022.
4
A Library of Chassis Strains for Morphology Engineering Connects Strain Fitness and Filamentous Growth With Submerged Macromorphology.用于形态工程的底盘菌株文库将菌株适应性和丝状生长与深层宏观形态联系起来。
Front Bioeng Biotechnol. 2022 Jan 17;9:820088. doi: 10.3389/fbioe.2021.820088. eCollection 2021.
本文引用的文献
1
Perturbation analysis of a multi-morphogen Turing reaction-diffusion stripe patterning system reveals key regulatory interactions.扰动向分析揭示了多形态素图灵反应扩散条纹模式系统的关键调控相互作用。
Development. 2020 Oct 29;147(20):dev190553. doi: 10.1242/dev.190553.
2
Positional information and reaction-diffusion: two big ideas in developmental biology combine.位置信息与反应扩散：发育生物学中的两大理念交汇
Development. 2015 Apr 1;142(7):1203-11. doi: 10.1242/dev.114991.
3
Hox genes regulate digit patterning by controlling the wavelength of a Turing-type mechanism.Hox 基因通过控制图灵型机制的波长来调节数字模式。
Science. 2012 Dec 14;338(6113):1476-80. doi: 10.1126/science.1226804.
4
Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system.节结和 Lef 差异扩散性为反应扩散模式系统提供基础。
Science. 2012 May 11;336(6082):721-4. doi: 10.1126/science.1221920. Epub 2012 Apr 12.
5
Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate.周期性条纹形成由图灵机制在哺乳动物腭部生长区起作用。
Nat Genet. 2012 Feb 19;44(3):348-51. doi: 10.1038/ng.1090.
6
WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism.WNT和DKK通过反应扩散机制决定毛囊间距。
Science. 2006 Dec 1;314(5804):1447-50. doi: 10.1126/science.1130088. Epub 2006 Nov 2.
7
A theory of biological pattern formation.一种生物模式形成的理论。
Kybernetik. 1972 Dec;12(1):30-9. doi: 10.1007/BF00289234.
8
Drosophila development: making stripes inelegantly.
Nature. 1989 Sep 28;341(6240):282-3. doi: 10.1038/341282a0.
Zotero 插件