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通过降低血清病毒体相关DNA聚合酶来测定单磷酸阿糖腺苷和9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤对土拨鼠肝炎病毒的体内活性。

Activities of arabinosyladenine monophosphate and 9-(1,3-dihydroxy-2-propoxymethyl)guanine against ground squirrel hepatitis virus in vivo as determined by reduction in serum virion-associated DNA polymerase.

作者信息

Smee D F, Knight S S, Duke A E, Robinson W S, Matthews T R, Marion P L

出版信息

Antimicrob Agents Chemother. 1985 Feb;27(2):277-9. doi: 10.1128/AAC.27.2.277.

DOI:10.1128/AAC.27.2.277
PMID:2580482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176255/
Abstract

Treatment of chronic ground squirrel hepatitis virus infection with arabinosyladenine monophosphate at 20 mg/kg per day for 3 weeks caused marked decreases in serum virion-associated DNA polymerase concentrations in three of five squirrels. Statistically significant but less dramatic decreases in enzymatic activity were noted in two of six squirrels treated with 50 mg of 9-(1,3-dihydroxy-2-propoxymethyl)guanine per kg per day. After therapy, DNA polymerase activities rose to pretreatment levels.

摘要

以每天20毫克/千克的单磷酸阿糖腺苷治疗慢性地松鼠肝炎病毒感染3周，导致五只松鼠中有三只的血清病毒体相关DNA聚合酶浓度显著下降。在每天每千克给予50毫克9-(1,3-二羟基-2-丙氧基甲基)鸟嘌呤治疗的六只松鼠中，有两只的酶活性出现了统计学上显著但不太明显的下降。治疗后，DNA聚合酶活性回升至治疗前水平。

相似文献

1
Activities of arabinosyladenine monophosphate and 9-(1,3-dihydroxy-2-propoxymethyl)guanine against ground squirrel hepatitis virus in vivo as determined by reduction in serum virion-associated DNA polymerase.通过降低血清病毒体相关DNA聚合酶来测定单磷酸阿糖腺苷和9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤对土拨鼠肝炎病毒的体内活性。
Antimicrob Agents Chemother. 1985 Feb;27(2):277-9. doi: 10.1128/AAC.27.2.277.
2
A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.一种存在于比奇地松鼠体内、与人类乙肝病毒相关的病毒。
Proc Natl Acad Sci U S A. 1980 May;77(5):2941-5. doi: 10.1073/pnas.77.5.2941.
3
Comparison of the effects of arabinosyladenine, arabinosylhypoxanthine, and arabinosyladenine 5'-monophosphate against herpes simplex virus, varicella-zoster virus, and cytomegalovirus with their effects on cellular deoxyribonucleic acid synthesis.阿糖腺苷、阿糖次黄嘌呤和阿糖腺苷5'-单磷酸对单纯疱疹病毒、水痘-带状疱疹病毒和巨细胞病毒的作用及其对细胞脱氧核糖核酸合成的作用的比较。
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4
Effect of combinations of acyclovir with vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in mice.阿昔洛韦与阿糖腺苷或其5'-单磷酸酯联合使用对细胞培养物和小鼠中单纯疱疹病毒的影响。
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5
Adenine arabinoside monophosphate and acyclovir monophosphate coupled to lactosaminated albumin reduce woodchuck hepatitis virus viremia at doses lower than do the unconjugated drugs.
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6
In vitro and in vivo activities of phosphate derivatives of 9-(1,3-dihydroxy-2-propoxymethyl)-guanine against cytomegaloviruses.9-(1,3-二羟基-2-丙氧基甲基)鸟嘌呤的磷酸盐衍生物对巨细胞病毒的体外和体内活性
Antiviral Res. 1986 Aug;6(5):299-308. doi: 10.1016/0166-3542(86)90025-2.
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Effect of ganciclovir [9-(1,3-dihydroxy-2-propoxymethyl)guanine] on viral DNA and protein synthesis in cells infected with herpes simplex virus.更昔洛韦[9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤]对单纯疱疹病毒感染细胞中病毒DNA和蛋白质合成的影响。
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Comparative activities of combinations of acyclovir, vidarabine or its 5'-monophosphate, and cloned human interferons against herpes simplex virus type 2 in human and mouse fibroblast cultures.
Antiviral Res. 1985 Dec;5(6):325-33. doi: 10.1016/0166-3542(85)90002-6.
9
Differential inhibition of mammalian DNA polymerases alpha, beta and gamma and herpes simplex virus-induced DNA polymerase by the 5'-triphosphates of arabinosyladenine and arabinosylcytosine.阿拉伯糖基腺嘌呤和阿拉伯糖基胞嘧啶的5'-三磷酸对哺乳动物DNA聚合酶α、β和γ以及单纯疱疹病毒诱导的DNA聚合酶的差异抑制作用。
IARC Sci Publ (1971). 1978(24 Pt 2):999-1005.
10
No in vivo effect of trisodium phosphonoformate on woodchuck hepatitis virus production.膦甲酸钠三钠对土拨鼠肝炎病毒产生无体内效应。
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引用本文的文献

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2
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3
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5
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Drugs. 1990 Apr;39(4):597-638. doi: 10.2165/00003495-199039040-00008.

本文引用的文献

1
Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus.与人类乙型肝炎病毒具有结构和生物学相关性的北京鸭病毒。
J Virol. 1980 Dec;36(3):829-36. doi: 10.1128/JVI.36.3.829-836.1980.
2
A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.一种存在于比奇地松鼠体内、与人类乙肝病毒相关的病毒。
Proc Natl Acad Sci U S A. 1980 May;77(5):2941-5. doi: 10.1073/pnas.77.5.2941.
3
Ground squirrel hepatitis virus infection.地松鼠肝炎病毒感染
Hepatology. 1983 Jul-Aug;3(4):519-27. doi: 10.1002/hep.1840030408.
4
Acyclovir in hepatitis B antigen-positive chronic liver disease: inhibition of viral replication and transient renal impairment with iv bolus administration.阿昔洛韦用于乙肝抗原阳性慢性肝病：静脉推注给药对病毒复制的抑制作用及短暂性肾功能损害
J Antimicrob Chemother. 1983 Mar;11(3):223-31. doi: 10.1093/jac/11.3.223.
5
Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine.无环核苷9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤的抗疱疹病毒活性
Antimicrob Agents Chemother. 1983 May;23(5):676-82. doi: 10.1128/AAC.23.5.676.
6
Ground squirrel hepatitis virus DNA: molecular cloning and comparison with hepatitis B virus DNA.地松鼠肝炎病毒DNA：分子克隆及与乙型肝炎病毒DNA的比较
J Virol. 1981 Apr;38(1):393-7. doi: 10.1128/JVI.38.1.393-397.1981.
7
State of hepatitis B viral DNA in a human hepatoma cell line.人肝癌细胞系中乙肝病毒DNA的状态
J Virol. 1980 Feb;33(2):795-806. doi: 10.1128/JVI.33.2.795-806.1980.
8
Comparison of properties of woodchuck hepatitis virus and human hepatitis B virus endogenous DNA polymerases.土拨鼠肝炎病毒与人乙型肝炎病毒内源性DNA聚合酶特性的比较。
Antimicrob Agents Chemother. 1984 Feb;25(2):242-6. doi: 10.1128/AAC.25.2.242.
9
No in vivo effect of trisodium phosphonoformate on woodchuck hepatitis virus production.膦甲酸钠三钠对土拨鼠肝炎病毒产生无体内效应。
Acta Pathol Microbiol Immunol Scand B. 1982 Dec;90(6):449-51. doi: 10.1111/j.1699-0463.1982.tb00145.x.
10
Adenine arabinoside 5'-monophosphate treatment of chronic type B hepatitis.阿糖腺苷5'-单磷酸治疗慢性乙型肝炎。
Hepatology. 1982 Nov-Dec;2(6):784-8. doi: 10.1002/hep.1840020606.