通过降低血清病毒体相关DNA聚合酶来测定单磷酸阿糖腺苷和9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤对土拨鼠肝炎病毒的体内活性。
Activities of arabinosyladenine monophosphate and 9-(1,3-dihydroxy-2-propoxymethyl)guanine against ground squirrel hepatitis virus in vivo as determined by reduction in serum virion-associated DNA polymerase.
作者信息
Smee D F, Knight S S, Duke A E, Robinson W S, Matthews T R, Marion P L
出版信息
Antimicrob Agents Chemother. 1985 Feb;27(2):277-9. doi: 10.1128/AAC.27.2.277.
Abstract
Treatment of chronic ground squirrel hepatitis virus infection with arabinosyladenine monophosphate at 20 mg/kg per day for 3 weeks caused marked decreases in serum virion-associated DNA polymerase concentrations in three of five squirrels. Statistically significant but less dramatic decreases in enzymatic activity were noted in two of six squirrels treated with 50 mg of 9-(1,3-dihydroxy-2-propoxymethyl)guanine per kg per day. After therapy, DNA polymerase activities rose to pretreatment levels.
摘要
以每天20毫克/千克的单磷酸阿糖腺苷治疗慢性地松鼠肝炎病毒感染3周，导致五只松鼠中有三只的血清病毒体相关DNA聚合酶浓度显著下降。在每天每千克给予50毫克9-(1,3-二羟基-2-丙氧基甲基)鸟嘌呤治疗的六只松鼠中，有两只的酶活性出现了统计学上显著但不太明显的下降。治疗后，DNA聚合酶活性回升至治疗前水平。
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Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus.与人类乙型肝炎病毒具有结构和生物学相关性的北京鸭病毒。
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A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.一种存在于比奇地松鼠体内、与人类乙肝病毒相关的病毒。
Proc Natl Acad Sci U S A. 1980 May;77(5):2941-5. doi: 10.1073/pnas.77.5.2941.
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Ground squirrel hepatitis virus infection.地松鼠肝炎病毒感染
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Acyclovir in hepatitis B antigen-positive chronic liver disease: inhibition of viral replication and transient renal impairment with iv bolus administration.阿昔洛韦用于乙肝抗原阳性慢性肝病：静脉推注给药对病毒复制的抑制作用及短暂性肾功能损害
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Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine.无环核苷9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤的抗疱疹病毒活性
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No in vivo effect of trisodium phosphonoformate on woodchuck hepatitis virus production.膦甲酸钠三钠对土拨鼠肝炎病毒产生无体内效应。
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Hepatology. 1982 Nov-Dec;2(6):784-8. doi: 10.1002/hep.1840020606.
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