Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne , Melbourne, VIC , Australia ; Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet , Stockholm , Sweden.
Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne , Melbourne, VIC , Australia ; Unit of Metabolism, Department of Medicine Huddinge, Karolinska Institutet , Stockholm , Sweden.
Front Psychiatry. 2015 Mar 10;6:34. doi: 10.3389/fpsyt.2015.00034. eCollection 2015.
Psychomotor disturbances (PMD) are a classic feature of depressive disorder that provides rich clinical information. The aim our narrative review was to characterize the functional anatomy of PMD by summarizing findings from neuroimaging studies. We found evidence across several neuroimaging modalities that suggest involvement of fronto-striatal neurocircuitry, and monoaminergic pathways and metabolism. We suggest that PMD in major depressive disorder emerge from an alteration of limbic signals, which influence emotion, volition, higher-order cognitive functions, and movement.
精神运动障碍（PMD）是抑郁症的典型特征，提供了丰富的临床信息。我们的叙述性综述旨在通过总结神经影像学研究的结果来描述 PMD 的功能解剖结构。我们发现，几种神经影像学模式都有证据表明，额叶-纹状体神经回路、单胺能通路和代谢都参与其中。我们认为，主要抑郁症中的 PMD 是由边缘信号的改变引起的，这些信号影响情绪、意志、高级认知功能和运动。
