Bibb Sophia A, Yu Emily J, Molloy M Fiona, LaRocco John, Resnick Patricia, Reeves Kevin, Phan K Luan, Krishna Sanjay, Saygin Zeynep M
Department of Psychology, The Ohio State University, Columbus, OH, United States.
Department of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Front Hum Neurosci. 2025 Mar 13;19:1514087. doi: 10.3389/fnhum.2025.1514087. eCollection 2025.
No prior work has directly compared the impacts of transcranial photobiomodulation (tPBM) and transcranial magnetic stimulation (TMS) on the human brain. This within-subjects pilot study compares the effects of tPBM and TMS of human somatomotor cortex on brain structural and functional connectivity. Eight healthy participants underwent four lab visits each, each visit consisting of a pre-stimulation MRI, stimulation or sham, and a post-stimulation MRI, respectively. Stimulation and sham sessions were counterbalanced across subjects. Collected measures included structural MRI data, functional MRI data from a finger-tapping task, resting state functional connectivity, and structural connectivity. Analyses indicated increased activation of the left somatomotor region during a right-hand finger-tapping task following both tPBM and TMS. Additionally, trending increases in left-lateralized functional and structural connectivity from M1 to thalamus were observed after tPBM, but not TMS. Thus, tPBM may be superior to TMS at inducing changes in connected nodes in the somatomotor cortex, although further research is warranted to explore the potential therapeutic benefits and clinical utility of tPBM.
此前没有研究直接比较过经颅光生物调节（tPBM）和经颅磁刺激（TMS）对人脑的影响。这项受试者自身对照的初步研究比较了tPBM和TMS对人类躯体运动皮层的影响，包括脑结构和功能连接性。八名健康参与者每人接受四次实验室检查，每次检查分别包括刺激前磁共振成像（MRI）、刺激或假刺激，以及刺激后MRI。刺激和假刺激环节在受试者之间进行了平衡处理。收集的测量指标包括结构MRI数据、来自手指敲击任务的功能MRI数据、静息态功能连接性和结构连接性。分析表明，在tPBM和TMS之后，右手手指敲击任务期间左侧躯体运动区域的激活增加。此外，tPBM后观察到从M1到丘脑的左侧功能和结构连接性有增加趋势，但TMS后未观察到。因此，在诱导躯体运动皮层连接节点变化方面，tPBM可能优于TMS，不过仍需要进一步研究来探索tPBM的潜在治疗益处和临床应用价值。
