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皮肤电极将信号传输到膀胱,从而改善了糖尿病兔模型中的膀胱低动力。

Skin electrodes transduced signals to the bladder resulting in ameliorated hypomotility in a rabbit model of diabetes.

机构信息

Department of Endocrinology and Metabolism, the Second Clinical Medical College of Jinan University (Shenzhen People's Hospital), Shenzhen 518020, Guangdong Province, China.

Department of Physics & Astronomy, McMaster University, Medical Physics, Hamilton L8S 4L8, Ontario, Canada.

出版信息

Neural Regen Res. 2012 Feb 5;7(4):308-12. doi: 10.3969/j.issn.1673-5374.2012.04.012.

DOI:10.3969/j.issn.1673-5374.2012.04.012
PMID:25806074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4353105/
Abstract

Electric signals from a chest skin electrode can be conducted to the heart and activate contraction. In the present study, normal and diabetic rabbits were stimulated by skin electrode on the abnormal bladder projection area using three levels of exporting voltage (5.84 V, 8.00 V, and 11.00 V). Results demonstrated significantly attenuated electric signals from both groups, in particular the diabetes group. The skin electrode signals were conducted to the bladders, and all vesical signals increased according to strength of stimulating signals from the skin electrode. However, vesical signals from diabetic rabbits were less than those from normal rabbits at the same stimulating strength of exporting voltage. Vesical pressures from the two groups increased along with increased vesical signals, but vesical pressure was less those from diabetic rabbits than in normal rabbits (basic status and different stimulating levels). Linear correlation analysis showed a significantly positive correlation between vesical pressure and signal. These results demonstrated that electric signals from skin electrodes resulted in increased vesical pressure, and vesical pressure increased along with stimulation strength.

摘要

皮肤电极的电信号可以传入心脏并引发收缩。在本研究中,正常和糖尿病兔子的异常膀胱投影区域接受皮肤电极刺激,导出电压分别为 5.84V、8.00V 和 11.00V。结果表明两组的电信号都明显减弱,尤其是糖尿病组。皮肤电极信号传入膀胱,随着皮肤电极刺激信号的增强,所有膀胱信号都增加。然而,在相同的导出电压刺激强度下,糖尿病兔子的膀胱信号小于正常兔子。两组的膀胱压力随着膀胱信号的增加而增加,但糖尿病兔子的膀胱压力小于正常兔子(基础状态和不同刺激水平)。线性相关分析显示膀胱压力与信号之间呈显著正相关。这些结果表明,皮肤电极的电信号导致膀胱压力增加,并且膀胱压力随着刺激强度的增加而增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f030/4353105/10a21a5456d3/NRR-7-308-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f030/4353105/10a21a5456d3/NRR-7-308-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f030/4353105/10a21a5456d3/NRR-7-308-g004.jpg

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本文引用的文献

1
The Starling mechanism of the urinary bladder contractile function and the influence of hyperglycemia on diabetic rats.膀胱收缩功能的 Starling 机制及高血糖对糖尿病大鼠的影响。
J Diabetes Complications. 2010 Mar-Apr;24(2):121-8. doi: 10.1016/j.jdiacomp.2009.06.002. Epub 2009 Aug 11.
2
Design of an implant for preventing incontinence after spinal cord injury.一种用于预防脊髓损伤后尿失禁的植入物的设计。
Artif Organs. 2008 Aug;32(8):586-91. doi: 10.1111/j.1525-1594.2008.00606.x.
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Morphological changes of cholinergic nerve fibers in the urinary bladder after establishment of artificial somatic-autonomic reflex arc in rats.
大鼠人工体神经-内脏神经反射弧建立后膀胱胆碱能神经纤维的形态学变化
Neurosci Bull. 2007 Sep;23(5):277-81. doi: 10.1007/s12264-007-0041-y.
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An endoscopically implantable device stimulates the lower esophageal sphincter on demand by remote control: a study using a canine model.一种可通过内镜植入的装置可根据需要通过遥控刺激食管下括约肌:一项使用犬模型的研究。
Endoscopy. 2007 Jan;39(1):72-6. doi: 10.1055/s-2006-945102.
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Using the nerve stimulator for peripheral or plexus nerve blocks.使用神经刺激器进行外周或神经丛神经阻滞。
Minerva Anestesiol. 2006 Jun;72(6):467-71.
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The use of electrical devices for the treatment of bladder dysfunction: a review of methods.用于治疗膀胱功能障碍的电气设备:方法综述
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