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一名T细胞急性淋巴细胞白血病青少年幸存者的隐球菌性骨髓炎。

Cryptococcal osteomyelitis in an adolescent survivor of T-cell acute lymphoblastic leukemia.

作者信息

Oh Djin-Ye, Madhusoodhan P Pallavi, Springer Deborah J, Inglima Kenneth, Chaudhri Ali A, Heitman Joseph, Raetz Elizabeth A, Khaitan Alka, Rigaud Mona

机构信息

From the *Saul Krugman Division of Pediatric Infectious Diseases, Department of Pediatrics, New York University Medical School, New York, NY; †Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA; ‡Division of Pediatric Hematology and Oncology, Department of Pediatrics, New York University Medical School, New York, NY; §Department of Molecular Genetics and Microbiology (MGM), ¶Department of Pharmacology and Cancer Biology, and ‖Department of Medicine, Duke University Medical Center, Durham, NC; **Department of Pathology, New York University Medical School, New York, NY; and ††Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT.

出版信息

Pediatr Infect Dis J. 2015 Jun;34(6):662-6. doi: 10.1097/INF.0000000000000687.

DOI:10.1097/INF.0000000000000687
PMID:25806844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4431918/
Abstract

Cryptococcosis is infrequent in children, and isolated cryptococcal osteomyelitis is rarely encountered. Here, we describe a 14-year-old patient in remission from T-cell acute lymphoblastic leukemia with osteomyelitis because of Cryptococcus neoformans var. grubii. The patient was effectively treated with antifungal therapy.

摘要

隐球菌病在儿童中并不常见,孤立性隐球菌性骨髓炎更是罕见。在此,我们描述一名14岁的患者,其T细胞急性淋巴细胞白血病处于缓解期,却因新型隐球菌格鲁比变种感染而患上骨髓炎。该患者通过抗真菌治疗得到了有效治疗。

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本文引用的文献

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Fungal Genet Biol. 2015 May;78:49-54. doi: 10.1016/j.fgb.2014.10.003. Epub 2014 Oct 13.
2
Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal.在南加州导致艾滋病患者感染的新型隐球菌格特变种VGIII分离株:确定当地环境来源为树栖环境。
PLoS Pathog. 2014 Aug 21;10(8):e1004285. doi: 10.1371/journal.ppat.1004285. eCollection 2014 Aug.
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Fungal diagnosis: how do we do it and can we do better?
以肱骨骨髓炎为首发症状的复发性急性淋巴细胞白血病的外科治疗:一例报告及文献复习
Ann Transl Med. 2021 Apr;9(8):722. doi: 10.21037/atm-21-1112.
真菌诊断:我们如何做才能做得更好?
Curr Med Res Opin. 2013 Apr;29 Suppl 4:3-11. doi: 10.1185/03007995.2012.761134.
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A comparison of cases of paediatric-onset and adult-onset cryptococcosis detected through population-based surveillance, 2005-2007.2005-2007 年基于人群的监测发现的儿童期和成年期隐球菌病病例比较。
AIDS. 2012 Nov 28;26(18):2307-14. doi: 10.1097/QAD.0b013e3283570567.
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Cryptococcal osteomyelitis in a child with a novel compound mutation of the IL12RB1 gene.儿童新型 IL12RB1 基因突变致隐球菌性骨髓炎
Asian Pac J Allergy Immunol. 2012 Mar;30(1):79-82.
7
Analyses of pediatric isolates of Cryptococcus neoformans from South Africa.南非新型隐球菌小儿分离株分析。
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