Medaris Leigh Ann, Ponce Brent, Hyde Zane, Delgado Dennis, Ennis David, Lapidus William, Larrison Matthew, Pappas Peter G
Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.
Division of Orthopedic Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Mycoses. 2016 Jun;59(6):334-42. doi: 10.1111/myc.12476. Epub 2016 Mar 10.
Cryptococcus neoformans is a fungal pathogen associated with advanced HIV disease and other disorders associated with immune dysfunction. The pulmonary and the central nervous system are the most common manifestations of the disease. Localised osteomyelitis as the sole manifestation of extrapulmonary disease is rare. Herein, we present five cases of Cryptococcus osteomyelitis as the only manifestation of extrapulmonary disease. We also identified 84 additional cases of isolated cryptococcal osteomyelitis in the literature. Using these data, we have made some general recommendations regarding an approach to treatment of this uncommon clinical entity.
新型隐球菌是一种与晚期艾滋病以及其他免疫功能障碍相关疾病有关的真菌病原体。肺部和中枢神经系统是该疾病最常见的表现部位。局限性骨髓炎作为肺外疾病的唯一表现较为罕见。在此，我们报告5例新型隐球菌骨髓炎作为肺外疾病的唯一表现病例。我们还在文献中识别出另外84例孤立性隐球菌骨髓炎病例。利用这些数据，我们针对这种不常见临床病症的治疗方法提出了一些一般性建议。
