MHC结构与功能——抗原呈递。第2部分。
MHC structure and function - antigen presentation. Part 2.
作者信息
Goldberg Anna Carla, Rizzo Luiz Vicente
机构信息
Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
出版信息
Einstein (Sao Paulo). 2015 Jan-Mar;13(1):157-62. doi: 10.1590/S1679-45082015RB3123. Epub 2015 Mar 24.
Abstract
The second part of this review deals with the molecules and processes involved in the processing and presentation of the antigenic fragments to the T-cell receptor. Though the nature of the antigens presented varies, the most significant class of antigens is proteins, processed within the cell to be then recognized in the form of peptides, a mechanism that confers an extraordinary degree of precision to this mode of immune response. The efficiency and accuracy of this system is also the result of the myriad of mechanisms involved in the processing of proteins and production of peptides, in addition to the capture and recycling of alternative sources aiming to generate further diversity in the presentation to T-cells.
摘要
本综述的第二部分探讨了与抗原片段加工及呈递给T细胞受体相关的分子和过程。尽管所呈递抗原的性质各异，但最重要的一类抗原是蛋白质，其在细胞内进行加工，随后以肽的形式被识别，这一机制赋予了这种免疫反应模式极高的精准度。该系统的效率和准确性也是多种参与蛋白质加工和肽生成的机制的结果，此外还包括捕获和循环利用替代来源，旨在增加呈递给T细胞的多样性。
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