Altmann-Schneider Irmhild, de Craen Anton J M, van den Berg-Huysmans Annette A, Slagboom Pieternella, Westendorp Rudi G J, van Buchem Mark A, van der Grond Jeroen
Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands; Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands; Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.
PLoS One. 2015 Mar 25;10(3):e0120778. doi: 10.1371/journal.pone.0120778. eCollection 2015.
This study aimed to investigate whether magnetization transfer imaging (MTI) parameters of cortical gray and white matter and subcortical gray matter structures differ between subjects enriched for human familial longevity and control subjects to provide a thorough description of the brain phenotype of familial longevity. Moreover, we aimed to describe cerebral ageing effects on MTI parameters in an elderly cohort. All subjects were included from the Leiden Longevity Study and underwent 3 Tesla MTI of the brain. In total, 183 offspring of nonagenarian siblings, who are enriched for familial factors of longevity, were contrasted with 163 environmentally and age-matched controls. No differences in cortical and subcortical gray matter and white matter MTI parameters were found between offspring and control subjects using histogram-based and voxel-wise analyses. Cortical gray matter and white matter MTI parameters decreased with increasing chronological age (all p < 0.001). Decrease of white matter magnetization transfer ratio (MTR) was homogeneous throughout the whole mean white matter skeleton except for parts of the callosal splenium and partly the posterior limb of the internal capsule and superior region of the corona radiata (p < 0.05). Mean MTR of subcortical gray matter structures decreased with increasing age (p amygdala, caudate nucleus and putamen < 0.001; p pallidum = 0.001, p thalamus = 0.002). In conclusion, the brain phenotype of human familial longevity is - at a mean age of 66 years - not characterized by preserved macromolecular brain tissue integrity.
本研究旨在调查富含人类家族长寿因素的受试者与对照受试者之间，皮质灰质、白质和皮质下灰质结构的磁化传递成像（MTI）参数是否存在差异，以全面描述家族长寿的脑表型。此外，我们旨在描述老年队列中脑老化对MTI参数的影响。所有受试者均来自莱顿长寿研究，并接受了脑部3特斯拉MTI检查。总共，183名百岁老人兄弟姐妹的后代（他们富含长寿的家族因素）与163名环境和年龄匹配的对照者进行了对比。使用基于直方图和体素的分析方法，未在后代和对照受试者之间发现皮质和皮质下灰质以及白质MTI参数存在差异。皮质灰质和白质MTI参数随实际年龄的增加而降低（所有p<0.001）。白质磁化传递率（MTR）的降低在整个平均白质骨架中是均匀的，但胼胝体压部的部分区域、内囊后肢的部分区域以及放射冠的上部区域除外（p<0.05）。皮质下灰质结构的平均MTR随年龄增加而降低（杏仁核、尾状核和壳核的p<0.001；苍白球的p = 0.001，丘脑的p = 0.002）。总之，在平均年龄为66岁时，人类家族长寿的脑表型并非以保留的大分子脑组织完整性为特征。
