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支原体对哺乳动物中间丝的抗原模拟

Antigenic mimicry of mammalian intermediate filaments by mycoplasmas.

作者信息

Wise K S, Watson R K

出版信息

Infect Immun. 1985 May;48(2):587-91. doi: 10.1128/iai.48.2.587-591.1985.

DOI:10.1128/iai.48.2.587-591.1985
PMID:2580796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC261390/
Abstract

A murine monoclonal antibody raised against Mycoplasma hyorhinis specifically reacted by indirect immunofluorescence with mammalian intermediate filaments. The antibody recognized a related epitope on a 74,000-molecular-weight protein of M. hyorhinis and on components of similar size from other pathogenic mycoplasmas. This defines a shared antigenic structure of interest in autoantibody development during mycoplasmal diseases.

摘要

一种针对猪鼻支原体产生的鼠单克隆抗体,通过间接免疫荧光法与哺乳动物中间丝发生特异性反应。该抗体识别猪鼻支原体一种分子量为74,000的蛋白质上的相关表位以及其他致病性支原体中类似大小的成分上的相关表位。这确定了在支原体疾病期间自身抗体产生过程中一种具有潜在重要性的共同抗原结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7aa/261390/362bd6f7d8e4/iai00116-0325-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7aa/261390/7aae7e559ff0/iai00116-0324-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7aa/261390/362bd6f7d8e4/iai00116-0325-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7aa/261390/7aae7e559ff0/iai00116-0324-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7aa/261390/362bd6f7d8e4/iai00116-0325-a.jpg

相似文献

1
Antigenic mimicry of mammalian intermediate filaments by mycoplasmas.支原体对哺乳动物中间丝的抗原模拟
Infect Immun. 1985 May;48(2):587-91. doi: 10.1128/iai.48.2.587-591.1985.
2
Antigenic mimicry of a human cellular polypeptide by Mycoplasma hyorhinis.猪鼻支原体对一种人类细胞多肽的抗原模拟
Infect Immun. 1987 Jul;55(7):1680-5. doi: 10.1128/iai.55.7.1680-1685.1987.
3
Monoclonal antibodies to Mycoplasma hyorhinis surface antigens: tools for analyzing mycoplasma-lymphoid cell interactions.抗猪鼻支原体表面抗原的单克隆抗体:分析支原体与淋巴细胞相互作用的工具。
Yale J Biol Med. 1983 Sep-Dec;56(5-6):623-9.
4
The Vlp system of Mycoplasma hyorhinis: combinatorial expression of distinct size variant lipoproteins generating high-frequency surface antigenic variation.猪鼻支原体的Vlp系统:不同大小变异脂蛋白的组合表达产生高频表面抗原变异。
J Bacteriol. 1991 Aug;173(15):4782-93. doi: 10.1128/jb.173.15.4782-4793.1991.
5
Mycoplasma hyorhinis GDL surface protein antigen p120 defined by monoclonal antibody.由单克隆抗体鉴定的猪鼻支原体GDL表面蛋白抗原p120
Infect Immun. 1983 Sep;41(3):1332-9. doi: 10.1128/iai.41.3.1332-1339.1983.
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Lipid-modified surface protein antigens expressing size variation within the species Mycoplasma hyorhinis.猪鼻支原体种内表达大小变异的脂质修饰表面蛋白抗原。
Infect Immun. 1989 Jan;57(1):245-54. doi: 10.1128/iai.57.1.245-254.1989.
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Assessment of antibody response of swine infected with Mycoplasma hyopneumoniae by immunoblotting.通过免疫印迹法评估感染猪肺炎支原体的猪的抗体反应。
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Triton X-114 phase fractionation of an integral membrane surface protein mediating monoclonal antibody killing of Mycoplasma hyorhinis.介导单克隆抗体杀伤猪鼻支原体的整合膜表面蛋白的Triton X-114相分离
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Human mycoplasmal infections: serologic observations.人类支原体感染:血清学观察
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10
Mapping of a Mycoplasma-Neutralizing Epitope on the Mycoplasmal p37 Protein.支原体p37蛋白上一个支原体中和表位的定位
PLoS One. 2016 Dec 30;11(12):e0169091. doi: 10.1371/journal.pone.0169091. eCollection 2016.

引用本文的文献

1
Association of lipids with integral membrane surface proteins of Mycoplasma hyorhinis.猪鼻支原体脂质与整合膜表面蛋白的关联
Infect Immun. 1988 Feb;56(2):295-301. doi: 10.1128/iai.56.2.295-301.1988.
2
Cloning and sequence analysis of cytadhesin P1 gene from Mycoplasma pneumoniae.肺炎支原体细胞黏附素P1基因的克隆与序列分析
Infect Immun. 1987 Dec;55(12):3023-9. doi: 10.1128/iai.55.12.3023-3029.1987.
3
Lipid-modified surface protein antigens expressing size variation within the species Mycoplasma hyorhinis.猪鼻支原体种内表达大小变异的脂质修饰表面蛋白抗原。

本文引用的文献

1
Cytoskeletal elements in mycoplasmas and other prokaryotes.支原体及其他原核生物中的细胞骨架成分。
Biosystems. 1981;14(3-4):305-12. doi: 10.1016/0303-2647(81)90037-x.
2
Intermediate filaments as mechanical integrators of cellular space.中间丝作为细胞空间的机械整合器。
Nature. 1980 Jan 17;283(5744):249-256. doi: 10.1038/283249a0.
3
IgM autoantibody to intermediate filaments in Mycoplasma pneumoniae infections.肺炎支原体感染中针对中间丝的IgM自身抗体。
Infect Immun. 1989 Jan;57(1):245-54. doi: 10.1128/iai.57.1.245-254.1989.
4
Antigenic mimicry of a human cellular polypeptide by Mycoplasma hyorhinis.猪鼻支原体对一种人类细胞多肽的抗原模拟
Infect Immun. 1987 Jul;55(7):1680-5. doi: 10.1128/iai.55.7.1680-1685.1987.
5
Triton X-114 phase fractionation of an integral membrane surface protein mediating monoclonal antibody killing of Mycoplasma hyorhinis.介导单克隆抗体杀伤猪鼻支原体的整合膜表面蛋白的Triton X-114相分离
Infect Immun. 1987 May;55(5):1094-100. doi: 10.1128/iai.55.5.1094-1100.1987.
6
Autoantibodies in infectious mononucleosis have specificity for the glycine-alanine repeating region of the Epstein-Barr virus nuclear antigen.传染性单核细胞增多症中的自身抗体对爱泼斯坦-巴尔病毒核抗原的甘氨酸-丙氨酸重复区域具有特异性。
J Exp Med. 1987 Apr 1;165(4):1026-40. doi: 10.1084/jem.165.4.1026.
Clin Immunol Immunopathol. 1981 Mar;18(3):425-30. doi: 10.1016/0090-1229(81)90135-5.
4
Phylogenetic analysis of the mycoplasmas.支原体的系统发育分析。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):494-8. doi: 10.1073/pnas.77.1.494.
5
Naturally occurring antibodies against nine common antigens in humans sera. II. High incidence of monoclonal Ig exhibiting antibody activity against actin and tubulin and sharing antibody specificities with natural antibodies.人血清中针对九种常见抗原的天然抗体。II. 具有抗肌动蛋白和微管蛋白抗体活性且与天然抗体具有共同抗体特异性的单克隆Ig的高发生率
J Immunol. 1982 Jun;128(6):2788-92.
6
Filamentous structures in adherent Mycoplasma pneumoniae cells treated with nonionic detergents.用非离子去污剂处理的粘附性肺炎支原体细胞中的丝状结构。
J Cell Biol. 1981 Nov;91(2 Pt 1):537-43. doi: 10.1083/jcb.91.2.537.
7
Mycoplasma-mediated activation of normal mouse lymphocytes: induction of cytotoxic lymphocytes and lymphocyte transformation by Mycoplasma arthritidis are under Ir gene control.支原体介导的正常小鼠淋巴细胞激活:关节炎支原体诱导的细胞毒性淋巴细胞和淋巴细胞转化受Ir基因控制。
J Immunol. 1981 Mar;126(3):922-7.
8
Mycoplasmas as agents of human disease.支原体作为人类疾病的病原体。
N Engl J Med. 1981 Jan 8;304(2):80-9. doi: 10.1056/NEJM198101083040204.
9
Infection with vaccinia favors the selection of hybridomas synthesizing autoantibodies against intermediate filaments, one of them cross-reacting with the virus hemagglutinin.接种牛痘病毒后有利于选择能合成针对中间丝的自身抗体的杂交瘤,其中一种自身抗体可与病毒血凝素发生交叉反应。
J Immunol. 1983 Sep;131(3):1546-53.
10
Mycoplasma hyorhinis GDL surface protein antigen p120 defined by monoclonal antibody.由单克隆抗体鉴定的猪鼻支原体GDL表面蛋白抗原p120
Infect Immun. 1983 Sep;41(3):1332-9. doi: 10.1128/iai.41.3.1332-1339.1983.