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1
Binding activity of a murine anti-lipid A monoclonal antibody.一种鼠抗脂质A单克隆抗体的结合活性。
Infect Immun. 1985 May;48(2):597-600. doi: 10.1128/iai.48.2.597-600.1985.
2
Neutralization of Shwartzman-inducing activity by antibodies recognizing the Re core or lipid A structures of lipopolysaccharide from Salmonella minnesota R595 and Pseudomonas vesicularis JCM1477.识别来自明尼苏达沙门氏菌R595和泡囊假单胞菌JCM1477的脂多糖的Re核心或脂多糖A结构的抗体对施瓦茨曼诱导活性的中和作用。
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Monoclonal antibodies to Salmonella lipopolysaccharide: anti-O-polysaccharide antibodies protect C3H mice against challenge with virulent Salmonella typhimurium.抗沙门氏菌脂多糖的单克隆抗体：抗O-多糖抗体可保护C3H小鼠免受强毒鼠伤寒沙门氏菌的攻击。
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Monoclonal antibodies demonstrate multiple epitopes on the O antigens of Salmonella typhimurium LPS.单克隆抗体在鼠伤寒沙门氏菌脂多糖的O抗原上显示出多个表位。
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9
Antigenic and immunogenic properties of recombinants from Salmonella typhimurium and Salmonella minnesota rough mutants expressing in their lipopolysaccharide a genus-specific chlamydial epitope.鼠伤寒沙门氏菌和明尼苏达沙门氏菌粗糙突变体的重组体的抗原性和免疫原性特性，这些重组体在其脂多糖中表达一种属特异性衣原体表位。
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Characterization of specific binding of a human immunoglobulin M monoclonal antibody to lipopolysaccharide and its lipid A domain.人免疫球蛋白M单克隆抗体与脂多糖及其脂质A结构域的特异性结合特性
Infect Immun. 1993 Mar;61(3):910-8. doi: 10.1128/iai.61.3.910-918.1993.

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Cross-reactivity of monoclonal antibodies and sera directed against lipid A and lipopolysaccharides.针对脂质A和脂多糖的单克隆抗体及血清的交叉反应性。
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Immunotherapeutic advances in the treatment of gram-negative bacterial sepsis.
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Monoclonal antibodies to salmonella lipopolysaccharide: functional analysis of anti-lipid A antibodies.抗沙门氏菌脂多糖单克隆抗体：抗脂质A抗体的功能分析
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Murine monoclonal antibodies to Klebsiella pneumoniae protect against lethal endotoxemia and experimental infection with capsulated K. pneumoniae.针对肺炎克雷伯菌的鼠单克隆抗体可预防致死性内毒素血症及由荚膜型肺炎克雷伯菌引起的实验性感染。
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本文引用的文献

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Determination of anti-lipid A and lipid A by enzyme immunoassay.通过酶免疫测定法测定抗脂质A和脂质A
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Characterization of murine antibody response to Salmonella typhimurium by a class-specific solid-phase radioimmunoassay.通过类特异性固相放射免疫测定法对小鼠抗鼠伤寒沙门氏菌抗体反应的表征。
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Genetically conferred defect in anti-Salmonella antibody formation renders CBA/N mice innately susceptible to Salmonella typhimurium infection.抗沙门氏菌抗体形成的基因缺陷使CBA/N小鼠天生易受鼠伤寒沙门氏菌感染。
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Lipopolysaccharides: structural principles and biologic activities.脂多糖：结构原理与生物学活性
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In vitro stimulation of C3H/HeJ spleen cells and macrophages by a lipid A precursor molecule derived from Salmonella typhimurium.鼠伤寒沙门氏菌来源的脂多糖A前体分子对C3H/HeJ脾细胞和巨噬细胞的体外刺激作用
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Immunogenic properties of lipid A.脂多糖A的免疫原性特性。
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Monoclonal antibodies demonstrate multiple epitopes on the O antigens of Salmonella typhimurium LPS.单克隆抗体在鼠伤寒沙门氏菌脂多糖的O抗原上显示出多个表位。
J Immunol. 1984 Oct;133(4):2255-60.
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Salmonella enteritis. II. Fulminant diarrhea in and effects on the small intestine.肠炎沙门氏菌。二、暴发性腹泻及其对小肠的影响。
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Preparation and properties of antisera against the lipid-A component of bacterial lipopolysaccharides.抗细菌脂多糖脂质A成分抗血清的制备及特性
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10
Reconstitution of a functional membrane enzyme system in a monomolecular film. I. Formation of a mixed monolayer of lipopolysaccharide and phospholipid.单分子膜中功能性膜酶系统的重构。I. 脂多糖与磷脂混合单分子层的形成。
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一种鼠抗脂质A单克隆抗体的结合活性。

Binding activity of a murine anti-lipid A monoclonal antibody.

作者信息

Elkins K, Metcalf E S

出版信息

Infect Immun. 1985 May;48(2):597-600. doi: 10.1128/iai.48.2.597-600.1985.

DOI:10.1128/iai.48.2.597-600.1985
PMID:2580797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC261394/
Abstract

In this report we briefly describe an immunoglobulin G3 monoclonal antibody, 2G6/1H11, which binds purified lipid A from Salmonella minnesota and a lipid A precursor molecule derived from Salmonella typhimurium. 2G6/1H11 does not bind well to purified whole S. typhimurium lipopolysaccharide (LPS), S. minnesota LPS, LPS preparations from a series of S. minnesota rough mutants, or intact S. typhimurium bacteria. Thus, there are antigenic determinants in purified lipid A which are not exposed when lipid A is presented as part of the whole LPS molecule or intact bacteria.

摘要

在本报告中，我们简要描述了一种免疫球蛋白G3单克隆抗体2G6/1H11，它能与来自明尼苏达沙门氏菌的纯化脂多糖A以及源自鼠伤寒沙门氏菌的一种脂多糖A前体分子结合。2G6/1H11与纯化的完整鼠伤寒沙门氏菌脂多糖（LPS）、明尼苏达沙门氏菌LPS、一系列明尼苏达沙门氏菌粗糙突变体的LPS制剂或完整的鼠伤寒沙门氏菌细菌结合不佳。因此，纯化的脂多糖A中存在一些抗原决定簇，当脂多糖A作为完整LPS分子或完整细菌的一部分呈现时，这些抗原决定簇不会暴露。