一种鼠抗脂质A单克隆抗体的结合活性。
Binding activity of a murine anti-lipid A monoclonal antibody.
作者信息
Elkins K, Metcalf E S
出版信息
Infect Immun. 1985 May;48(2):597-600. doi: 10.1128/iai.48.2.597-600.1985.
Abstract
In this report we briefly describe an immunoglobulin G3 monoclonal antibody, 2G6/1H11, which binds purified lipid A from Salmonella minnesota and a lipid A precursor molecule derived from Salmonella typhimurium. 2G6/1H11 does not bind well to purified whole S. typhimurium lipopolysaccharide (LPS), S. minnesota LPS, LPS preparations from a series of S. minnesota rough mutants, or intact S. typhimurium bacteria. Thus, there are antigenic determinants in purified lipid A which are not exposed when lipid A is presented as part of the whole LPS molecule or intact bacteria.
摘要
在本报告中，我们简要描述了一种免疫球蛋白G3单克隆抗体2G6/1H11，它能与来自明尼苏达沙门氏菌的纯化脂多糖A以及源自鼠伤寒沙门氏菌的一种脂多糖A前体分子结合。2G6/1H11与纯化的完整鼠伤寒沙门氏菌脂多糖（LPS）、明尼苏达沙门氏菌LPS、一系列明尼苏达沙门氏菌粗糙突变体的LPS制剂或完整的鼠伤寒沙门氏菌细菌结合不佳。因此，纯化的脂多糖A中存在一些抗原决定簇，当脂多糖A作为完整LPS分子或完整细菌的一部分呈现时，这些抗原决定簇不会暴露。
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本文引用的文献
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