顽固性高血压患者中性粒细胞与淋巴细胞比值升高
Increased Neutrophil to Lymphocyte Ratio in Patients With Resistant Hypertension.
作者信息
Belen Erdal, Sungur Aylin, Sungur Mustafa Azmi, Erdoğan Güney
机构信息
Department of Cardiology, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
Department of Cardiology, Kahramanmaras Necip Fazıl City Hospital, Kahramanmaras, Turkey.
出版信息
J Clin Hypertens (Greenwich). 2015 Jul;17(7):532-7. doi: 10.1111/jch.12533. Epub 2015 Mar 23.
Abstract
Resistant hypertension (RHT) is an important disease that causes an increase in cardiovascular risk, yet its etiology remains unclear. The authors aimed to investigate neutrophil/lymphocyte ratio (NLR) as an inflammation marker in patients with RHT. A total of 150 patients were included in the study and grouped according to their office and ambulatory blood pressure measurements. They were classified as having normotension (NT), controlled hypertension (CHT), or RHT. The RHT group had a significantly higher NLR than the CHT group (P=.03), and NLRs of both hypertension groups were significantly higher than those in the NT group (P<.001, for both). NLR and neutrophil count were found to be independent correlates for RHT in multivariate analysis (P<.001). NLR and neutrophil count are increased in RHT patients than both CHT and NT patients. This finding, which is defined for the first time in patients with RHT, may imply the importance of inflammation in blood pressure control.
摘要
顽固性高血压（RHT）是一种导致心血管风险增加的重要疾病，但其病因仍不清楚。作者旨在研究中性粒细胞/淋巴细胞比率（NLR）作为RHT患者炎症标志物的情况。该研究共纳入150例患者，并根据其诊室血压和动态血压测量结果进行分组。他们被分为血压正常（NT）、血压控制良好的高血压（CHT）或RHT。RHT组的NLR显著高于CHT组（P = 0.03），且两个高血压组的NLR均显著高于NT组（两者P均<0.001）。在多变量分析中，NLR和中性粒细胞计数被发现是RHT的独立相关因素（P<0.001）。RHT患者的NLR和中性粒细胞计数高于CHT和NT患者。这一首次在RHT患者中发现的结果可能意味着炎症在血压控制中的重要性。
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2
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Blood Press. 2015 Feb;24(1):7-13. doi: 10.3109/08037051.2014.940710. Epub 2014 Jul 25.
3
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J Cardiovasc Pharmacol. 2013 Oct;62(4):388-93. doi: 10.1097/FJC.0b013e31829f716a.
4
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Angiology. 2013 Aug;64(6):456-65. doi: 10.1177/0003319712455216. Epub 2012 Aug 16.
5
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J Hypertens. 2012 May;30(5):967-73. doi: 10.1097/HJH.0b013e3283521484.
6
7
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8
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J Am Soc Hypertens. 2010 Nov-Dec;4(6):272-83. doi: 10.1016/j.jash.2010.09.005. Epub 2010 Oct 27.
9
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10
Proinflammation and hypertension: a population-based study.炎症与高血压：一项基于人群的研究。
Mediators Inflamm. 2008;2008:619704. doi: 10.1155/2008/619704. Epub 2008 Dec 30.
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