Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792, USA,
Curr Infect Dis Rep. 2015 Feb;17(2):452. doi: 10.1007/s11908-014-0452-7.
There are several extrahepatic cutaneous manifestations associated with hepatitis B and hepatitis C virus infection. Serum sickness and polyarteritis nodosa are predominantly associated with hepatitis B infection, whereas mixed cryoglobulinemia associated vasculitis and porphyria cutanea tarda are more frequently seen in hepatitis C infection. The clinico-pathogenic associations of these skin conditions are not completely defined but appear to involve activation of the host immune system including the complement system. Management of the aforementioned cutaneous manifestations of viral hepatitis is often similar to that done in cases without viral hepatitis, with control of immune activation being a key strategy. In cases associated with hepatitis B and C, control of viral replication with specific antiviral therapy is also important and associated with improvement in most of the associated clinical manifestations.
有几种与乙型肝炎和丙型肝炎病毒感染相关的肝外皮肤表现。血清病和结节性多动脉炎主要与乙型肝炎感染相关，而混合性冷球蛋白血症相关血管炎和迟发性皮肤卟啉症则更常见于丙型肝炎感染。这些皮肤疾病的临床病理关联尚未完全明确，但似乎涉及宿主免疫系统的激活，包括补体系统。病毒性肝炎上述皮肤表现的治疗通常与无病毒性肝炎的情况相似，控制免疫激活是关键策略。在与乙型肝炎和丙型肝炎相关的情况下，通过特定的抗病毒治疗控制病毒复制也很重要，并且与大多数相关临床表现的改善相关。
