Powell J B, Gach J E
Department of Dermatology, Worcestershire Royal Hospital, Worcester, UK.
Department of Dermatology, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, UK.
Clin Exp Dermatol. 2015 Aug;40(6):605-10. doi: 10.1111/ced.12626. Epub 2015 Mar 21.
Elderly patients present with a unique spectrum of dermatoses that pose particular management opportunities and challenges, which will be increasingly encountered in dermatological practice. The skin of elderly patients differs from that of younger patients not only in appearance but also in structure, physiology and response to ultraviolet (UV) radiation. However, little is known about the safety and efficacy of phototherapy in elderly patients and how phototherapy is currently being utilized to treat them.
To investigate the safety, efficacy and utilization of phototherapy in elderly patients.
In January 2014, we analysed all patients recently referred for, currently receiving or recently having completed a course of phototherapy at a university teaching hospital in England (UK).
In total, 249 patients were identified; 37 (15%) were over the age of 65 years (the WHO definition of an elderly or older person). The dermatoses being treated were psoriasis (51%), eczema (11%), nodular prurigo (11%), pruritus (11%), Grover disease (5%) and others (11%). One patient with dementia was deemed not safe to embark on phototherapy, and five patients were yet to start. The remaining 31 elderly patients received 739 individual phototherapy treatments: 88% narrowband (NB)-UVB and 12% systemic, bath and hand/foot psoralen UVA (PUVA). The acute adverse event (AE) rate was 1.89%, all occurring in those receiving NB-UVB. No severe acute AEs occurred. Of those who completed their course of phototherapy, 80% achieved a clear/near clear or moderate response, while just two patients (8%) had minimal response and two (8%) had worsening of the disease during treatment. Of those receiving NB-UVB for psoriasis, 91% achieved a clear or near-clear response.
In this small survey, the first of its kind to focus on elderly patients, phototherapy appears to be well-tolerated, safe and efficacious in the short term. Further thought and investigation should be given to delivering phototherapy to an ageing population.
老年患者患有一系列独特的皮肤病,这带来了特殊的管理机遇和挑战,在皮肤科实践中这类情况会越来越常见。老年患者的皮肤与年轻患者的皮肤不仅在外观上不同,在结构、生理以及对紫外线(UV)辐射的反应方面也存在差异。然而,对于老年患者光疗的安全性和有效性以及目前如何利用光疗来治疗他们,人们了解甚少。
调查老年患者光疗的安全性、有效性及应用情况。
2014年1月,我们分析了英国一家大学教学医院近期转诊来的、正在接受或刚完成一个光疗疗程的所有患者。
共识别出249例患者;37例(15%)年龄超过65岁(世界卫生组织对老年人的定义)。所治疗的皮肤病包括银屑病(51%)、湿疹(11%)、结节性痒疹(11%)、瘙痒症(11%)、格罗弗病(5%)及其他(11%)。一名痴呆患者被认为不适合进行光疗,还有五名患者尚未开始治疗。其余31例老年患者接受了739次个体光疗:88%为窄谱中波紫外线(NB-UVB),12%为全身、浴用及手足补骨脂素长波紫外线(PUVA)。急性不良事件(AE)发生率为1.89%,均发生在接受NB-UVB治疗的患者中。未发生严重急性AE。完成光疗疗程的患者中,80%达到了清除/接近清除或中度缓解,而仅有两名患者(8%)缓解甚微,两名患者(8%)在治疗期间病情加重。接受NB-UVB治疗银屑病的患者中,91%达到了清除或接近清除的缓解。
在这项首次聚焦于老年患者的小型调查中,光疗在短期内似乎耐受性良好、安全且有效。对于向老龄化人群提供光疗,应进行进一步的思考和研究。