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老年患者银屑病窄谱中波紫外线光疗的7年回顾性研究

A 7-Year Retrospective Study of Narrowband Ultraviolet B Phototherapy for Psoriasis in Geriatric Patients.

作者信息

Legiawati Lili, Astriningrum Rinadewi, Yusharyahya Shannaz N, Chandrakesuma Vivianne, Pulungan Andria A

机构信息

From the Department of Dermatology and Venereology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Faculty of Medicine, Universitas Indonesia, Indonesia.

出版信息

Indian J Dermatol. 2025 Mar-Apr;70(2):53-56. doi: 10.4103/ijd.ijd_184_23. Epub 2025 Feb 27.

DOI:10.4103/ijd.ijd_184_23
PMID:40162363
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11952716/
Abstract

BACKGROUND

Complications of psoriasis may add to the burden of degenerative diseases already present in elderly patients. Phototherapy is a well-established treatment for psoriasis, and narrowband ultraviolet B (NB-UVB) is currently the first-line phototherapy for psoriasis. Its use in elderly has been assessed and is found to be safe and efficacious for many dermatoses.

AIMS AND OBJECTIVES

To learn the efficacy and safety of NB-UVB phototherapy in geriatric patients with psoriasis in Indonesia.

MATERIALS AND METHODS

A retrospective study using data from medical records of psoriasis patients aged ≥60 who received NB-UVB phototherapy at the dermatovenereology outpatient clinic of Dr. Cipto Mangunkusumo National General Hospital in 2014-2020. The data were processed using SPSS version 25, and descriptive analysis was conducted.

RESULTS

From 30 patients, 75% reduction of Psoriasis Area and Severity Index was accomplished by 14 patients (47%) after a median of 21 sessions and a median cumulative dose of 25.7 J/cm2. The side effects were experienced by nine patients (30%), comprising pain, burn, and itch. No patient experienced more than two episodes of erythema during their treatment. Most side effects are mild and do not require discontinuation of therapy.

CONCLUSIONS

NB-UVB phototherapy is safe and effective for geriatric patients with psoriasis.

摘要

背景

银屑病的并发症可能会加重老年患者已有的退行性疾病负担。光疗是一种成熟的银屑病治疗方法,窄谱中波紫外线(NB-UVB)是目前银屑病的一线光疗方法。其在老年人中的应用已得到评估,发现对许多皮肤病安全有效。

目的

了解NB-UVB光疗在印度尼西亚老年银屑病患者中的疗效和安全性。

材料与方法

一项回顾性研究,使用2014年至2020年在西托·曼贡库苏莫国家综合医院皮肤科门诊接受NB-UVB光疗的≥60岁银屑病患者的病历数据。使用SPSS 25版对数据进行处理,并进行描述性分析。

结果

30例患者中,14例(47%)在中位21次治疗和中位累积剂量25.7 J/cm²后银屑病面积和严重程度指数降低了75%。9例患者(30%)出现副作用,包括疼痛、灼伤和瘙痒。在治疗期间,没有患者出现超过两次的红斑发作。大多数副作用较轻,无需中断治疗。

结论

NB-UVB光疗对老年银屑病患者安全有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecd/11952716/95164eb3b503/IJD-70-53-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecd/11952716/95164eb3b503/IJD-70-53-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ecd/11952716/95164eb3b503/IJD-70-53-g001.jpg

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Ann Geriatr Med Res. 2020 Dec;24(4):290-296. doi: 10.4235/agmr.20.0048. Epub 2020 Dec 25.
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The efficacy and safety of phototherapy in geriatric patients: a retrospective study.
光疗在老年患者中的疗效与安全性:一项回顾性研究。
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