长期锂治疗会削弱黑腹果蝇雌性在寿命方面的优势。
Chronic lithium treatment diminishes the female advantage in lifespan in Drosophila melanogaster.
作者信息
Zhu Fengge, Li Qinggang, Zhang Fujian, Sun Xuefeng, Cai Guangyan, Zhang Weiguang, Chen Xiangmei
机构信息
Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.
出版信息
Clin Exp Pharmacol Physiol. 2015 Jun;42(6):617-21. doi: 10.1111/1440-1681.12393.
Two studies have concluded that lithium exposure extends the lifespan of Caenorhabditis elegans. However, the effect of lithium on another widely used model organism, Drosophila melanogaster, remains unclear. Here, we demonstrate that chronic treatment with a low to moderate dose of lithium chloride does not extend lifespan in D. melanogaster and that the drug abolishes the female lifespan advantage in flies.
两项研究得出结论，锂暴露可延长秀丽隐杆线虫的寿命。然而，锂对另一种广泛使用的模式生物黑腹果蝇的影响仍不清楚。在此，我们证明，用低至中等剂量的氯化锂进行慢性处理并不会延长黑腹果蝇的寿命，而且该药物消除了果蝇中的雌性寿命优势。
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