Hu Q, Li G, Yao H, He S, Li H, Liu S, Wu Y, Lai X
Guangzhou University of Chinese Medicine School of Chinese Herbal Medicine Guangzhou China.
Guangzhou University of Chinese Medicine Dongguan Mathematical Engineering Academy of Chinese Medicine Dongguan China
Cell Mol Biol (Noisy-le-grand). 2016 Apr 30;62(4):116-22.
In this study, we aims to investigate the effects of edible bird's nest (EBN) on anti-aging efficacy. In order to investigate lifespan and mortality rate of flies, we treated flies with various doses of EBN. Besides, fecundity, water content and food are determined and heat-stress test is conducted after flies treating with different medium. Effects of EBN on total antioxidant activity (T-AOC), super-oxide dismutase activity (SOD), catalase activity (CAT), and malondialdehyde (MDA) were examined in drosophila melanogaster. Results indicated that flies in EBN treated group illustrated significantly lower mortality rates and longer median and maximum lifespan compared to control group (P<0.05). The fecundity in EBN-treated group was increased compared to control group. SOD levels and CAT activity were significantly increased, and MDA levels decreased in EBN-treated group compared to control group (P<0.01). In conclusion, EBN can extend lifespan, decrease mortality rate and increase survival rate in heat-stress test, and which can also promote SOD and CAT activity and reduce MDA levels. EBN is able to delay drosophila melanogaster aging, attributing to the increasing antioxidant enzyme activities and decreasing content of lipid peroxidation products in drosophila melanogaster.
在本研究中，我们旨在探究食用燕窝（EBN）的抗衰老功效。为了研究果蝇的寿命和死亡率，我们用不同剂量的EBN处理果蝇。此外，在果蝇用不同培养基处理后，测定其繁殖力、含水量和食物摄入量，并进行热应激试验。在黑腹果蝇中检测了EBN对总抗氧化活性（T-AOC）、超氧化物歧化酶活性（SOD）、过氧化氢酶活性（CAT）和丙二醛（MDA）的影响。结果表明，与对照组相比，EBN处理组的果蝇死亡率显著降低，中位寿命和最大寿命更长（P<0.05）。与对照组相比，EBN处理组的繁殖力有所提高。与对照组相比，EBN处理组的SOD水平和CAT活性显著增加，MDA水平降低（P<0.01）。总之，EBN可以延长寿命，降低死亡率，并提高热应激试验中的存活率，还可以促进SOD和CAT活性，降低MDA水平。EBN能够延缓黑腹果蝇衰老，这归因于黑腹果蝇体内抗氧化酶活性的增加和脂质过氧化产物含量的降低。
