Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science & Technology, Tianjin 300457, China.
Arch Gerontol Geriatr. 2014 Jan-Feb;58(1):153-9. doi: 10.1016/j.archger.2013.07.007. Epub 2013 Aug 8.
Lutein is one of the major carotenoids in most fruits and vegetables. The effect of lutein on the lifespan of Drosophila melanogaster was investigated. Results revealed that 0.1mg lutein/ml diet could prolong their mean lifespan from 49.0 to 54.6 days. This was consistent with a significant reduction in malonyldialdehyde (MDA) level and increase in antioxidant enzyme activities of the flies fed with lutein-treated diet compared with those fed with basal diet. Paraquat (PQ) and H2O2 treatment tests demonstrated that lutein could prolong the survival time of the flies. Real-time polymerase chain reaction (RT-PCR) analysis indicated the gene expression of superoxide dismutase (SOD; SOD1 and SOD2), and catalase (CAT) in the lutein-treated group was up-regulated relative to that of the control group. It was concluded that the lifespan-prolonging activity of lutein was partially by up-regulation of endogenous antioxidant enzymes.
叶黄素是大多数水果和蔬菜中主要的类胡萝卜素之一。本研究调查了叶黄素对黑腹果蝇寿命的影响。结果表明，饮食中添加 0.1mg/ml 叶黄素可将果蝇的平均寿命从 49.0 天延长至 54.6 天。这与喂食叶黄素处理饮食的果蝇丙二醛（MDA）水平显著降低和抗氧化酶活性增加一致，而喂食基础饮食的果蝇 MDA 水平较高，抗氧化酶活性较低。百草枯（PQ）和 H2O2 处理试验表明，叶黄素能延长果蝇的存活时间。实时聚合酶链反应（RT-PCR）分析表明，与对照组相比，叶黄素处理组超氧化物歧化酶（SOD；SOD1 和 SOD2）和过氧化氢酶（CAT）的基因表达上调。因此，叶黄素的寿命延长活性部分是通过上调内源性抗氧化酶实现的。
