HMGA2、Survivin、CEACAM6和SFN/14-3-3δ在滤泡性甲状腺癌中的诊断价值
The Diagnostic Usefulness of HMGA2, Survivin, CEACAM6, and SFN/14-3-3 δ in Follicular Thyroid Carcinoma.
作者信息
Jang Min Hye, Jung Kyeong Cheon, Min Hye Sook
机构信息
Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea ; Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
出版信息
J Pathol Transl Med. 2015 Mar;49(2):112-7. doi: 10.4132/jptm.2015.01.31. Epub 2015 Mar 12.
BACKGROUND
Follicular thyroid carcinoma (FTC) is the second most common thyroid malignancy and its differential diagnosis includes follicular adenoma (FA) and adenomatous goiter (AG). Several ancillary markers have been suggested to aid in the diagnosis of FTC, but the successful use of these methods still needs to be validated.
METHODS
In the present study, we verified the immunoexpression of HMGA2, CEACAM6, survivin, and SFN/14-3-3 δ in lesions including 41 AGs, 72 FAs, and 79 FTCs. We evaluated their diagnostic usefulness, combined with galectin 3, Hector Battifora mesothelial 1 (HBME1), cytokeratin 19, and cyclin D1, in diagnosing FTC.
RESULTS
The expressions of HBME1 (65.8%) and HMGA2 (55.7%) were significantly higher in FTCs than in FAs and AGs (p<.001 and p=.005, respectively). HBME1 was the only marker that was more frequently expressed in FTCs than in FAs (p=.021) and it was more frequently expressed in follicular neoplasms than in AGs (p<.001). Among the novel markers, the combination of HMGA2 and HBME1 showed the highest sensitivity (72.2%) and specificity (76.1%) for diagnosing FTC. CEACAM6, survivin, and SFN/14-3-3 δ were barely expressed in most cases.
CONCLUSIONS
Our present results show that only HMGA2 can be beneficial in differentiating FTC using the novel markers.
背景
滤泡状甲状腺癌（FTC）是第二常见的甲状腺恶性肿瘤，其鉴别诊断包括滤泡性腺瘤（FA）和腺瘤性甲状腺肿（AG）。已有多种辅助标志物被提出用于辅助FTC的诊断，但这些方法的成功应用仍需验证。
方法
在本研究中，我们验证了高迁移率族蛋白A2（HMGA2）、癌胚抗原相关细胞黏附分子6（CEACAM6）、生存素和14-3-3δ在41例AG、72例FA和79例FTC病变中的免疫表达。我们评估了它们与半乳糖凝集素3、赫克托·巴蒂福拉间皮1（HBME1）、细胞角蛋白19和细胞周期蛋白D1联合用于诊断FTC的实用性。
结果
HBME1（65.8%）和HMGA2（55.7%）在FTC中的表达显著高于FA和AG（分别为p<0.001和p = 0.005）。HBME1是唯一在FTC中比在FA中更频繁表达的标志物（p = 0.021），且在滤泡性肿瘤中比在AG中更频繁表达（p<0.001）。在新标志物中，HMGA2和HBME1联合使用对FTC诊断的敏感性最高（72.2%），特异性为76.1%。在大多数情况下CEACAM6、生存素和14-3-3δ几乎不表达。
结论
我们目前的结果表明，在使用新标志物鉴别FTC时，只有HMGA2可能具有帮助。
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